Fibrin(ogen)olysis in polymyalgia rheumatica and temporal arteritis: Preliminary findings on association with disease activity

R. G. Grau, S. S. Kassan, J. J. Franks, H. Kaplan, S. H. Walker, E. M. Tan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Postulating an increased production of fibrin(ogen)olytic degradation products (FDP) and an abnormalitiy of fibrinogen metabolism in polymyalgia rheumatica (PMR) and temporal arteritis (TA), we studied 16 PMR/TA patients and 10 control subjects using a sensitive radioimmunoassay for a specific type of FDP, namely, fibrin(ogen)-related D-antigen. Median serum D-antigen levels were increased five-fold in those 11 PMR/TA patients who were untreated compared with control subjects. In the five PMR/TA patients who were treated with prednisone the median D-antigen levels were not significantly different from those of the controls. D-antigen concentration correlated significantly (r=0.83) with ESR in the seven untreated PMR patients. IN PMR patients prednisone therapy was followed by a reduction of serum D-antigen levels.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume43
Issue number5
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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