Fibroblast growth factor 2 control of vascular tone

Ming Zhou, Roy L. Sutliff, Richard J. Paul, John N. Lorenz, James B. Hoying, Christian C. Haudenschild, Moving Yin, J. Douglas Coffin, Ling Kong, Evangelia G. Kranias, Wusheng Luo, Gregory P. Boivin, John J. Duffy, Sharon A. Pawlowski, Thomas Doetschman

Research output: Contribution to journalArticle

277 Scopus citations

Abstract

Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. Fgf2 knockout mice are morphologically normal and display decreased vascular smooth muscle contractility, low blood pressure and thrombocytosuis. Following intra- arterial mechanical injury, FGF2-deficient vessels undergo a normal hyperplastic response. These results force us to reconsider the function of FGF2 in vascular development and homeostasis in terms of vascular tone control.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalNature Medicine
Volume4
Issue number2
DOIs
StatePublished - Apr 7 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Zhou, M., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Hoying, J. B., Haudenschild, C. C., Yin, M., Coffin, J. D., Kong, L., Kranias, E. G., Luo, W., Boivin, G. P., Duffy, J. J., Pawlowski, S. A., & Doetschman, T. (1998). Fibroblast growth factor 2 control of vascular tone. Nature Medicine, 4(2), 201-207. https://doi.org/10.1038/nm0298-201