Field-based multiplex and quantitative assay platforms for diagnostics

Srivatsa Venkatasubbarao, C. Edward Dixon, Russell A Chipman, Axel Scherer, Manal Beshay, Lothar U. Kempen, Jai Ganesh Chandra Sekhar, Hong Yan, Ava Puccio, David Okonkwo, Stephen C Mcclain, Noah Gilbert, Saurabh Vyawahare

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The U.S. military has a continued interest in the development of handheld, field-usable sensors and test kits for a variety of diagnostic applications, such as traumatic brain injury (TBI) and infectious diseases. Field-use presents unique challenges for biosensor design, both for the readout unit and for the biological assay platform. We have developed robust biosensor devices that offer ultra-high sensitivity and also meet field-use needs. The systems under development include a multiplexed quantitative lateral flow test strip for TBI diagnostics, a field test kit for the diagnosis of pathogens endemic to the Middle East, and a microfluidic assay platform with a label-free reader for performing complex biological automated assays in the field.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume8029
DOIs
Publication statusPublished - 2011
EventSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII - Orlando, FL, United States
Duration: Apr 25 2011Apr 27 2011

Other

OtherSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII
CountryUnited States
CityOrlando, FL
Period4/25/114/27/11

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Keywords

  • dipstick assay
  • field-based diagnostics
  • labelless detection
  • lateral flow immunoassay
  • lateral flow test strip
  • microfluidic chips
  • traumatic brain injury

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Venkatasubbarao, S., Dixon, C. E., Chipman, R. A., Scherer, A., Beshay, M., Kempen, L. U., ... Vyawahare, S. (2011). Field-based multiplex and quantitative assay platforms for diagnostics. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 8029). [80290P] https://doi.org/10.1117/12.886661