Field-based multiplex and quantitative assay platforms for diagnostics

Srivatsa Venkatasubbarao, C. Edward Dixon, Russell Chipman, Axel Scherer, Manal Beshay, Lothar U. Kempen, Jai Ganesh Chandra Sekhar, Hong Yan, Ava Puccio, David Okonkwo, Stephen McClain, Noah Gilbert, Saurabh Vyawahare

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The U.S. military has a continued interest in the development of handheld, field-usable sensors and test kits for a variety of diagnostic applications, such as traumatic brain injury (TBI) and infectious diseases. Field-use presents unique challenges for biosensor design, both for the readout unit and for the biological assay platform. We have developed robust biosensor devices that offer ultra-high sensitivity and also meet field-use needs. The systems under development include a multiplexed quantitative lateral flow test strip for TBI diagnostics, a field test kit for the diagnosis of pathogens endemic to the Middle East, and a microfluidic assay platform with a label-free reader for performing complex biological automated assays in the field.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII
DOIs
StatePublished - Jul 6 2011
EventSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII - Orlando, FL, United States
Duration: Apr 25 2011Apr 27 2011

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8029
ISSN (Print)0277-786X

Other

OtherSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII
CountryUnited States
CityOrlando, FL
Period4/25/114/27/11

Keywords

  • dipstick assay
  • field-based diagnostics
  • labelless detection
  • lateral flow immunoassay
  • lateral flow test strip
  • microfluidic chips
  • traumatic brain injury

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Venkatasubbarao, S., Dixon, C. E., Chipman, R., Scherer, A., Beshay, M., Kempen, L. U., Chandra Sekhar, J. G., Yan, H., Puccio, A., Okonkwo, D., McClain, S., Gilbert, N., & Vyawahare, S. (2011). Field-based multiplex and quantitative assay platforms for diagnostics. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII [80290P] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8029). https://doi.org/10.1117/12.886661