Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy

An analysis of 2,418 cases

Anil P Rama Rao, Raghavan Narasimhan, Vanaja Sankaran, Andrew Joseph Veliath

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

During a period of 5 yr, 2,418 fine-needle aspirations (FNA) were performed on 2,216 patients with superficial lymphadenopathy. Chronic nonspecific lymphadenitis was the commonest inflammatory lesion followed by tuberculosis. Among malignant lesions, metastatic tumors were most common followed by non-Hodgkin's lymphoma. The FNAC findings were correlated with subsequent histopathological diagnosis in 1,041 cases. The sensitivity rates of FNAC in tuberculosis, metastatic tumors, Hodgkin's disease, and non- Hodgkin's lymphoma were found to be 83.3, 97, 30, and 80.3%, respectively, the specificity being 94.3, 98.9, 98.6, and 95.4% in the same order. Immunocytochemical tests performed on the aspirated material helped in classifying the metastatic poorly differentiated tumors and confirming the diagnosis of non-Hodgkin's lymphomas. Effects of FNA on subsequent biopsy in 81 lymph nodes with benign hyperplasia were studied and showed that aspiration does trot interfere with subsequent histologic assessment. Thus FNAC is a simple, inexpensive procedure, and when complemented by appropriate immunocytochemical studies is accurate and reliable for routine diagnosis of lymphadenopathy.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalDiagnostic Cytopathology
Volume15
Issue number5
DOIs
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Fine Needle Biopsy
Non-Hodgkin's Lymphoma
Cell Biology
Tuberculosis
Neoplasms
Lymphadenitis
Hodgkin Disease
Hyperplasia
Lymph Nodes
Biopsy
Lymphadenopathy

Keywords

  • Aspiration
  • Immunocytochemistry
  • Superficial lymphadenopathy

ASJC Scopus subject areas

  • Anatomy

Cite this

Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy : An analysis of 2,418 cases. / Rama Rao, Anil P; Narasimhan, Raghavan; Sankaran, Vanaja; Veliath, Andrew Joseph.

In: Diagnostic Cytopathology, Vol. 15, No. 5, 12.1996, p. 382-386.

Research output: Contribution to journalArticle

Rama Rao, Anil P ; Narasimhan, Raghavan ; Sankaran, Vanaja ; Veliath, Andrew Joseph. / Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy : An analysis of 2,418 cases. In: Diagnostic Cytopathology. 1996 ; Vol. 15, No. 5. pp. 382-386.
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