Five-year results of thoracic endovascular aortic repair with the Zenith TX2

Jon S. Matsumura, Germano Melissano, Richard P. Cambria, Michael D. Dake, Shraddha Mehta, Lars G. Svensson, Randy D. Moore

Research output: Contribution to journalArticle

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Abstract

Background This trial evaluated thoracic endovascular aortic repair (TEVAR) compared with open surgical repair of descending thoracic aortic aneurysms and large ulcers at 42 international sites. Whereas several studies demonstrate early safety and utility advantages with TEVAR, longer follow-up is important because of concerns about durability of TEVAR. Methods This prospective, nonrandomized study enrolled 160 TEVAR patients treated with the Cook Zenith TX2 and 70 open surgical repair patients. Results Although follow-up was limited, 5-year mortality rate was similar at 37% for both groups. Aneurysm-related mortality rate was 5.9% with TEVAR compared with 12% with open surgical repair (P =.11). There were no ruptures of the treated aneurysms in either group or open conversions in the TEVAR group. Predefined severe morbidity occurred at a significantly lower rate in TEVAR (21%) compared with open surgical repair (39%; P <.001). Aneurysm growth was seen by core laboratory in 5.9% of patients and endoleak in 5.7% of patients. Secondary intervention rates were similar between TEVAR (8%) and open surgical repair (12%; P =.49) patients. Conclusions Five-year results indicate similar all-cause mortality and aneurysm-related mortality with TEVAR compared with open repair. There was a persistent reduction of severe complications with TEVAR. Reinterventions occurred with similar frequency. TEVAR with the TX2 is a safe and effective alternative to open surgical repair for the treatment of anatomically suitable descending thoracic aortic aneurysms and ulcers.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of vascular surgery
Volume60
Issue number1
DOIs
StatePublished - Jul 2014
Externally publishedYes

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Thorax
Aneurysm
Thoracic Aortic Aneurysm
Mortality
Ulcer
Endoleak
Rupture
Prospective Studies
Morbidity
Safety
Growth

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Matsumura, J. S., Melissano, G., Cambria, R. P., Dake, M. D., Mehta, S., Svensson, L. G., & Moore, R. D. (2014). Five-year results of thoracic endovascular aortic repair with the Zenith TX2. Journal of vascular surgery, 60(1), 1-10. https://doi.org/10.1016/j.jvs.2014.01.043

Five-year results of thoracic endovascular aortic repair with the Zenith TX2. / Matsumura, Jon S.; Melissano, Germano; Cambria, Richard P.; Dake, Michael D.; Mehta, Shraddha; Svensson, Lars G.; Moore, Randy D.

In: Journal of vascular surgery, Vol. 60, No. 1, 07.2014, p. 1-10.

Research output: Contribution to journalArticle

Matsumura, JS, Melissano, G, Cambria, RP, Dake, MD, Mehta, S, Svensson, LG & Moore, RD 2014, 'Five-year results of thoracic endovascular aortic repair with the Zenith TX2', Journal of vascular surgery, vol. 60, no. 1, pp. 1-10. https://doi.org/10.1016/j.jvs.2014.01.043
Matsumura, Jon S. ; Melissano, Germano ; Cambria, Richard P. ; Dake, Michael D. ; Mehta, Shraddha ; Svensson, Lars G. ; Moore, Randy D. / Five-year results of thoracic endovascular aortic repair with the Zenith TX2. In: Journal of vascular surgery. 2014 ; Vol. 60, No. 1. pp. 1-10.
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