TY - JOUR
T1 - Flavonoids
T2 - From cell cycle regulation to biotechnology
AU - Woo, Ho Hyung
AU - Jeong, Byeong Ryong
AU - Hawes, Martha C.
N1 - Funding Information:
The project was supported in part by the National Research Initiative of the USDA Cooperative State Research, Education and Extension Service, Grant number 2003-35304-13362; and Department of Energy, number defg0394er20164, to MCH and HHW. BRJ was supported in part by Daegu University Research Grant, 2004, and in part by Daegu University RRC Program. Part of this review has been presented at the 5th International Symposium of Biotechnology of Natural and Agricultural Products, Daegu, Korea, May 28–29, 2004.
PY - 2005/3
Y1 - 2005/3
N2 - Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
AB - Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
KW - Cell cycle regulation
KW - Flavonoids
KW - UDP-glucuronosyltransferase
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U2 - 10.1007/s10529-005-1521-7
DO - 10.1007/s10529-005-1521-7
M3 - Review article
C2 - 15834800
AN - SCOPUS:17744397185
VL - 27
SP - 365
EP - 374
JO - Biotechnology Letters
JF - Biotechnology Letters
SN - 0141-5492
IS - 6
ER -