Flavonoids: From cell cycle regulation to biotechnology

Ho Hyung Woo, Byeong Ryong Jeong, Martha C. Hawes

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).

Original languageEnglish (US)
Pages (from-to)365-374
Number of pages10
JournalBiotechnology Letters
Volume27
Issue number6
DOIs
StatePublished - Mar 1 2005

Keywords

  • Cell cycle regulation
  • Flavonoids
  • UDP-glucuronosyltransferase

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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