Abstract
Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-374 |
| Number of pages | 10 |
| Journal | Biotechnology Letters |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 2005 |
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Keywords
- Cell cycle regulation
- Flavonoids
- UDP-glucuronosyltransferase
ASJC Scopus subject areas
- Biotechnology
- Applied Microbiology and Biotechnology
- Microbiology
- Bioengineering
Cite this
Flavonoids : From cell cycle regulation to biotechnology. / Woo, Ho Hyung; Jeong, Byeong Ryong; Hawes, Martha C.
In: Biotechnology Letters, Vol. 27, No. 6, 03.2005, p. 365-374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flavonoids
T2 - From cell cycle regulation to biotechnology
AU - Woo, Ho Hyung
AU - Jeong, Byeong Ryong
AU - Hawes, Martha C
PY - 2005/3
Y1 - 2005/3
N2 - Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
AB - Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
KW - Cell cycle regulation
KW - Flavonoids
KW - UDP-glucuronosyltransferase
UR - http://www.scopus.com/inward/record.url?scp=17744397185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744397185&partnerID=8YFLogxK
U2 - 10.1007/s10529-005-1521-7
DO - 10.1007/s10529-005-1521-7
M3 - Article
C2 - 15834800
AN - SCOPUS:17744397185
VL - 27
SP - 365
EP - 374
JO - Biotechnology Letters
JF - Biotechnology Letters
SN - 0141-5492
IS - 6
ER -