Flow acceleration effect on canser cell deformation abd detachment

L. S L Cheung, X. J. Zheng, A. Stopa, Joyce Schroeder, Ronald L Heimark, James C Baygents, Roberto Z Guzman, Y. Zoharl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The effect of flow acceleration, rather than just the flow rate, on the response of an attached cancer cell is for the first time reported. Selective binding of prostate cancer cells to a surface functionalized with anti-N-cadherin antibodies utilizing a microfluidic system under flow conditions has been studied [1]. Here, the behavior of a captured cell under a time-dependent flow field is investigated experimentally and numerically. Under slowly increasing flow rate, the cell deformation is more pronounced resulting in lower drag force on attached cells. Furthermore, the contact area between the cell and the functionalized surface is larger, potentially enhancing the cell adhesion force. Consequently, a higher flow rate is required to detach cells exposed to such a flow field. Numerical simulations have been utilized in effort to quantify the required detachment force. The results confirm that to obtain a similar shear stress, a higher flow rate is needed for attached cells under lower flow acceleration.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages431-434
Number of pages4
DOIs
StatePublished - 2009
Event22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009 - Sorrento, Italy
Duration: Jan 25 2009Jan 29 2009

Other

Other22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009
CountryItaly
CitySorrento
Period1/25/091/29/09

Fingerprint

detachment
Flow rate
cells
flow velocity
Flow fields
Cells
Cell adhesion
Cadherins
Microfluidics
Antibodies
flow distribution
Contacts (fluid mechanics)
Drag
Shear stress
cancer
antibodies
Computer simulation
shear stress
drag
adhesion

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Cheung, L. S. L., Zheng, X. J., Stopa, A., Schroeder, J., Heimark, R. L., Baygents, J. C., ... Zoharl, Y. (2009). Flow acceleration effect on canser cell deformation abd detachment. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 431-434). [4805411] https://doi.org/10.1109/MEMSYS.2009.4805411

Flow acceleration effect on canser cell deformation abd detachment. / Cheung, L. S L; Zheng, X. J.; Stopa, A.; Schroeder, Joyce; Heimark, Ronald L; Baygents, James C; Guzman, Roberto Z; Zoharl, Y.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2009. p. 431-434 4805411.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cheung, LSL, Zheng, XJ, Stopa, A, Schroeder, J, Heimark, RL, Baygents, JC, Guzman, RZ & Zoharl, Y 2009, Flow acceleration effect on canser cell deformation abd detachment. in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)., 4805411, pp. 431-434, 22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009, Sorrento, Italy, 1/25/09. https://doi.org/10.1109/MEMSYS.2009.4805411
Cheung LSL, Zheng XJ, Stopa A, Schroeder J, Heimark RL, Baygents JC et al. Flow acceleration effect on canser cell deformation abd detachment. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2009. p. 431-434. 4805411 https://doi.org/10.1109/MEMSYS.2009.4805411
Cheung, L. S L ; Zheng, X. J. ; Stopa, A. ; Schroeder, Joyce ; Heimark, Ronald L ; Baygents, James C ; Guzman, Roberto Z ; Zoharl, Y. / Flow acceleration effect on canser cell deformation abd detachment. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2009. pp. 431-434
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