Flow measurement using speckle in optical coherence tomography images

Jennifer K Barton, Steven Stromski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Doppler optical coherence tomography (DOCT) is a valuable tool for depth-resolved flow measurements in tissue. However, DOCT suffers from two disadvantages: it is insensitive to flow in the direction normal to the imaging beam, and it requires knowledge of the phase of the demodulated signal. We present an alternative method of extracting flow information, using speckle of conventional amplitude optical coherence tomography images. The two techniques can be shown to be essentially equivalent, with the distinction that speckle methods are sensitive to flow in all directions but do not provide information on the direction of flow. It is well known in other imaging modalities that moving scatterers cause a time-varying speckle pattern. Due to the pixel-by-pixel acquisition scheme of conventional OCT, time-varying speckle is manifested as a change of OCT image spatial speckle frequencies. We tested the ability of speckle to provide quantitative flow information using a flow phantom (a tube filled with Intralipid flowing at a constant volumetric flow rate). Initially, m-scans were taken at over the center of the tube. Images were averaged to reduce noise and the region corresponding to the center one-quarter of the tube lumen was selected. Sequential a-scans were concatenated, the Fourier transform performed, and a ratio of high to low spatial frequencies computed. We found that, over a range of velocities, this ratio bore a linear relation to flow velocity. For two-dimensional imaging, the program was modified to use a sliding window. Parabolic flow profile was visualized inside the tube. This study shows the feasibility of extracting quantitative flow data in all directions without phase information.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages245-256
Number of pages12
Volume5690
DOIs
StatePublished - 2005
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
CountryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Fingerprint

Optical tomography
Flow measurement
Speckle
Imaging techniques
Pixels
Flow velocity
Fourier transforms
Flow rate
Tissue

Keywords

  • Doppler
  • Flow measurement
  • LASCA
  • Optical coherence tomography
  • Speckle

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Barton, J. K., & Stromski, S. (2005). Flow measurement using speckle in optical coherence tomography images. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5690, pp. 245-256). [43] https://doi.org/10.1117/12.589632

Flow measurement using speckle in optical coherence tomography images. / Barton, Jennifer K; Stromski, Steven.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 5690 2005. p. 245-256 43.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Barton, JK & Stromski, S 2005, Flow measurement using speckle in optical coherence tomography images. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5690, 43, pp. 245-256, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.589632
Barton JK, Stromski S. Flow measurement using speckle in optical coherence tomography images. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5690. 2005. p. 245-256. 43 https://doi.org/10.1117/12.589632
Barton, Jennifer K ; Stromski, Steven. / Flow measurement using speckle in optical coherence tomography images. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 5690 2005. pp. 245-256
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