Fluid percussion injury model

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Hallmarks of traumatic brain injury in man can be faithfully reproduced in the laboratory using fluid percussion injury. Variations in the surgical procedure provide the ability to induce focal diffuse or mixed focal and diffuse brain injury in various laboratory species. Being fully scalable, fluid percussion can induce mild, moderate, or severe brain injury in subjects of any age. This chapter outlines the procedures for midline (diffuse) fluid percussion brain injury in adult male Sprague-Dawley rats and lateral (mixed) fluid percussion brain injury in adult male mice. With these procedures, it becomes possible to generate brain-injured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.

Original languageEnglish (US)
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Pages369-384
Number of pages16
ISBN (Print)9781603271844
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Keywords

  • Brain injury
  • Fluid percussion
  • Mouse
  • Rat
  • Trauma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

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