Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

R. Andrew Wall, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8217
DOIs
StatePublished - 2012
EventEndoscopic Microscopy VII - San Francisco, CA, United States
Duration: Jan 22 2012Jan 23 2012

Other

OtherEndoscopic Microscopy VII
CountryUnited States
CitySan Francisco, CA
Period1/22/121/23/12

Fingerprint

endoscopes
Endoscopy
Endoscopes
Optical tomography
Optical Coherence Tomography
tomography
Fluorescence
fluorescence
Lenses
Colon
Visualization
lenses
gradient index optics
Molecular imaging
Imaging techniques
Molecular Imaging
fibers
Single mode fibers
Prisms
magnification

Keywords

  • Aberrant crypt foci (ACF)
  • Catheter
  • Colon
  • Endoscope
  • Gastrointestinal (GI)
  • Gradient-index (GRIN)
  • Optical coherence tomography (OCT)
  • Surface magnifying chromoendoscopy (SMC)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Andrew Wall, R., & Barton, J. K. (2012). Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8217). [821703] https://doi.org/10.1117/12.909291

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. / Andrew Wall, R.; Barton, Jennifer K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8217 2012. 821703.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Andrew Wall, R & Barton, JK 2012, Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8217, 821703, Endoscopic Microscopy VII, San Francisco, CA, United States, 1/22/12. https://doi.org/10.1117/12.909291
Andrew Wall R, Barton JK. Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8217. 2012. 821703 https://doi.org/10.1117/12.909291
Andrew Wall, R. ; Barton, Jennifer K. / Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8217 2012.
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