Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

R. Andrew Wall, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8217
DOIs
Publication statusPublished - 2012
EventEndoscopic Microscopy VII - San Francisco, CA, United States
Duration: Jan 22 2012Jan 23 2012

Other

OtherEndoscopic Microscopy VII
CountryUnited States
CitySan Francisco, CA
Period1/22/121/23/12

    Fingerprint

Cite this

Andrew Wall, R., & Barton, J. K. (2012). Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8217). [821703] https://doi.org/10.1117/12.909291