Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

Jatinder S. Josan, Channa R. De Silva, Byunghee Yoo, Ronald M. Lynch, Mark D. Pagel, Josef Vagner, Victor J. Hruby

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The use of fluorescent (or luminescent) and metal contrast agents in high-throughput screens, in vitro assays, and molecular imaging procedures has rapidly expanded in recent years. Here we describe the development and utility of high-affinity ligands for cancer theranostics and other in vitro screening -studies. In this context, we also illustrate the syntheses and use of heteromultivalent ligands as targeted imaging agents.

Original languageEnglish (US)
Pages (from-to)89-126
Number of pages38
JournalMethods in molecular biology (Clifton, N.J.)
Volume716
DOIs
StatePublished - May 24 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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