Fluticasone is associated with lower asthma-related costs than leukotriene modifiers in a real-world analysis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Study Objective. To compare the impact of fluticasone propionate versus three leukotriene modifiers - montelukast, zafirlukast, and zileuton - on the cost of asthma within a managed care organization. Design. Retrospective quasi-experimental comparison. Setting. Managed care organization with approximately 350,000 enrollees. Patients. Three hundred forty-seven patients with asthma who received at least two prescriptions for either fluticasone or a leukotriene modifier. Patients receiving both fluticasone and a leukotriene modifier were excluded. Measurements and Main Results. Multivariate analysis was used to compare total asthma-related costs between treatment groups. A significant difference in total asthma-related costs was found between patients receiving fluticasone (adjusted mean cost $511) compared with those receiving a leukotriene modifier ($1092; p=0.0001). Other significant predictors of postindex asthma-related costs were pre-index asthma-related costs, a severity adjustment score, and the diagnosis of chronic obstructive pulmonary disease. Patients taking a leukotriene modifier obtained more short-acting β-agonists than patients receiving fluticasone (6.49 ± 4.05 vs 4.30 ± 3.41, p<0.0001). A survival analysis of time to receive any additional controller therapy revealed that patients receiving fluticasone were significantly less likely to receive another controller than were those receiving a leukotriene modifier (p=0.0014). Conclusion. These results suggest that fluticasone is associated with lower asthma-related costs than leukotriene modifiers.

Original languageEnglish (US)
Pages (from-to)1117-1123
Number of pages7
JournalPharmacotherapy
Volume22
Issue number9 I
StatePublished - Sep 2002

Fingerprint

Leukotrienes
Asthma
Costs and Cost Analysis
montelukast
Managed Care Programs
zileuton
Organizations
Survival Analysis
Fluticasone
Health Care Costs
Chronic Obstructive Pulmonary Disease
Prescriptions
Multivariate Analysis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{ad6b16020c0946498c032b803926f8b8,
title = "Fluticasone is associated with lower asthma-related costs than leukotriene modifiers in a real-world analysis",
abstract = "Study Objective. To compare the impact of fluticasone propionate versus three leukotriene modifiers - montelukast, zafirlukast, and zileuton - on the cost of asthma within a managed care organization. Design. Retrospective quasi-experimental comparison. Setting. Managed care organization with approximately 350,000 enrollees. Patients. Three hundred forty-seven patients with asthma who received at least two prescriptions for either fluticasone or a leukotriene modifier. Patients receiving both fluticasone and a leukotriene modifier were excluded. Measurements and Main Results. Multivariate analysis was used to compare total asthma-related costs between treatment groups. A significant difference in total asthma-related costs was found between patients receiving fluticasone (adjusted mean cost $511) compared with those receiving a leukotriene modifier ($1092; p=0.0001). Other significant predictors of postindex asthma-related costs were pre-index asthma-related costs, a severity adjustment score, and the diagnosis of chronic obstructive pulmonary disease. Patients taking a leukotriene modifier obtained more short-acting β-agonists than patients receiving fluticasone (6.49 ± 4.05 vs 4.30 ± 3.41, p<0.0001). A survival analysis of time to receive any additional controller therapy revealed that patients receiving fluticasone were significantly less likely to receive another controller than were those receiving a leukotriene modifier (p=0.0014). Conclusion. These results suggest that fluticasone is associated with lower asthma-related costs than leukotriene modifiers.",
author = "Armstrong, {Edward P} and Malone, {Daniel C}",
year = "2002",
month = "9",
language = "English (US)",
volume = "22",
pages = "1117--1123",
journal = "Pharmacotherapy",
issn = "0277-0008",
publisher = "Pharmacotherapy Publications Inc.",
number = "9 I",

}

TY - JOUR

T1 - Fluticasone is associated with lower asthma-related costs than leukotriene modifiers in a real-world analysis

AU - Armstrong, Edward P

AU - Malone, Daniel C

PY - 2002/9

Y1 - 2002/9

N2 - Study Objective. To compare the impact of fluticasone propionate versus three leukotriene modifiers - montelukast, zafirlukast, and zileuton - on the cost of asthma within a managed care organization. Design. Retrospective quasi-experimental comparison. Setting. Managed care organization with approximately 350,000 enrollees. Patients. Three hundred forty-seven patients with asthma who received at least two prescriptions for either fluticasone or a leukotriene modifier. Patients receiving both fluticasone and a leukotriene modifier were excluded. Measurements and Main Results. Multivariate analysis was used to compare total asthma-related costs between treatment groups. A significant difference in total asthma-related costs was found between patients receiving fluticasone (adjusted mean cost $511) compared with those receiving a leukotriene modifier ($1092; p=0.0001). Other significant predictors of postindex asthma-related costs were pre-index asthma-related costs, a severity adjustment score, and the diagnosis of chronic obstructive pulmonary disease. Patients taking a leukotriene modifier obtained more short-acting β-agonists than patients receiving fluticasone (6.49 ± 4.05 vs 4.30 ± 3.41, p<0.0001). A survival analysis of time to receive any additional controller therapy revealed that patients receiving fluticasone were significantly less likely to receive another controller than were those receiving a leukotriene modifier (p=0.0014). Conclusion. These results suggest that fluticasone is associated with lower asthma-related costs than leukotriene modifiers.

AB - Study Objective. To compare the impact of fluticasone propionate versus three leukotriene modifiers - montelukast, zafirlukast, and zileuton - on the cost of asthma within a managed care organization. Design. Retrospective quasi-experimental comparison. Setting. Managed care organization with approximately 350,000 enrollees. Patients. Three hundred forty-seven patients with asthma who received at least two prescriptions for either fluticasone or a leukotriene modifier. Patients receiving both fluticasone and a leukotriene modifier were excluded. Measurements and Main Results. Multivariate analysis was used to compare total asthma-related costs between treatment groups. A significant difference in total asthma-related costs was found between patients receiving fluticasone (adjusted mean cost $511) compared with those receiving a leukotriene modifier ($1092; p=0.0001). Other significant predictors of postindex asthma-related costs were pre-index asthma-related costs, a severity adjustment score, and the diagnosis of chronic obstructive pulmonary disease. Patients taking a leukotriene modifier obtained more short-acting β-agonists than patients receiving fluticasone (6.49 ± 4.05 vs 4.30 ± 3.41, p<0.0001). A survival analysis of time to receive any additional controller therapy revealed that patients receiving fluticasone were significantly less likely to receive another controller than were those receiving a leukotriene modifier (p=0.0014). Conclusion. These results suggest that fluticasone is associated with lower asthma-related costs than leukotriene modifiers.

UR - http://www.scopus.com/inward/record.url?scp=0036708213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036708213&partnerID=8YFLogxK

M3 - Article

C2 - 12222547

AN - SCOPUS:0036708213

VL - 22

SP - 1117

EP - 1123

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 9 I

ER -