Focal adhesions

Paradigm for a signaling nexus

Lewis H. Romer, Konstantin G. Birukov, Joe GN Garcia

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a variety of environmental stimuli and mediate 2-way crosstalk between the extracellular matrix and the cytoskeleton. Focal adhesion components are targets for biochemical and mechanical stimuli that evoke crucial developmental and injury response mechanisms including cell growth, movement, and differentiation, and tailoring of the extracellular microenvironment. Focal adhesions provide the vascular wall constituents with flexible and specific tools for exchanging cues in a complex system. The molecular mechanisms that underlie these vital communications are detailed in this review with the goal of defining future targets for vascular tissue engineering and for the therapeutic modulation of disordered vascular growth, inflammation, thrombosis, and angiogenesis.

Original languageEnglish (US)
Pages (from-to)606-616
Number of pages11
JournalCirculation Research
Volume98
Issue number5
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Focal Adhesions
Blood Vessels
Intracellular Space
Tunica Intima
Extracellular Space
Tissue Engineering
Growth
Cytoskeleton
Endothelium
Cell Movement
Cues
Extracellular Matrix
Smooth Muscle
Cell Differentiation
Thrombosis
Communication
Inflammation
Nexus
Wounds and Injuries
Therapeutics

Keywords

  • Cell adhesion
  • Cell signaling
  • Extracellular matrix
  • Focal adhesion
  • Integrin
  • Mechanical force
  • Vascular endothelium
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Focal adhesions : Paradigm for a signaling nexus. / Romer, Lewis H.; Birukov, Konstantin G.; Garcia, Joe GN.

In: Circulation Research, Vol. 98, No. 5, 03.2006, p. 606-616.

Research output: Contribution to journalArticle

Romer, Lewis H. ; Birukov, Konstantin G. ; Garcia, Joe GN. / Focal adhesions : Paradigm for a signaling nexus. In: Circulation Research. 2006 ; Vol. 98, No. 5. pp. 606-616.
@article{4b2bbd19d9f744f6835d1d6999873e1d,
title = "Focal adhesions: Paradigm for a signaling nexus",
abstract = "The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a variety of environmental stimuli and mediate 2-way crosstalk between the extracellular matrix and the cytoskeleton. Focal adhesion components are targets for biochemical and mechanical stimuli that evoke crucial developmental and injury response mechanisms including cell growth, movement, and differentiation, and tailoring of the extracellular microenvironment. Focal adhesions provide the vascular wall constituents with flexible and specific tools for exchanging cues in a complex system. The molecular mechanisms that underlie these vital communications are detailed in this review with the goal of defining future targets for vascular tissue engineering and for the therapeutic modulation of disordered vascular growth, inflammation, thrombosis, and angiogenesis.",
keywords = "Cell adhesion, Cell signaling, Extracellular matrix, Focal adhesion, Integrin, Mechanical force, Vascular endothelium, Vascular smooth muscle",
author = "Romer, {Lewis H.} and Birukov, {Konstantin G.} and Garcia, {Joe GN}",
year = "2006",
month = "3",
doi = "10.1161/01.RES.0000207408.31270.db",
language = "English (US)",
volume = "98",
pages = "606--616",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Focal adhesions

T2 - Paradigm for a signaling nexus

AU - Romer, Lewis H.

AU - Birukov, Konstantin G.

AU - Garcia, Joe GN

PY - 2006/3

Y1 - 2006/3

N2 - The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a variety of environmental stimuli and mediate 2-way crosstalk between the extracellular matrix and the cytoskeleton. Focal adhesion components are targets for biochemical and mechanical stimuli that evoke crucial developmental and injury response mechanisms including cell growth, movement, and differentiation, and tailoring of the extracellular microenvironment. Focal adhesions provide the vascular wall constituents with flexible and specific tools for exchanging cues in a complex system. The molecular mechanisms that underlie these vital communications are detailed in this review with the goal of defining future targets for vascular tissue engineering and for the therapeutic modulation of disordered vascular growth, inflammation, thrombosis, and angiogenesis.

AB - The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a variety of environmental stimuli and mediate 2-way crosstalk between the extracellular matrix and the cytoskeleton. Focal adhesion components are targets for biochemical and mechanical stimuli that evoke crucial developmental and injury response mechanisms including cell growth, movement, and differentiation, and tailoring of the extracellular microenvironment. Focal adhesions provide the vascular wall constituents with flexible and specific tools for exchanging cues in a complex system. The molecular mechanisms that underlie these vital communications are detailed in this review with the goal of defining future targets for vascular tissue engineering and for the therapeutic modulation of disordered vascular growth, inflammation, thrombosis, and angiogenesis.

KW - Cell adhesion

KW - Cell signaling

KW - Extracellular matrix

KW - Focal adhesion

KW - Integrin

KW - Mechanical force

KW - Vascular endothelium

KW - Vascular smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=33645282289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645282289&partnerID=8YFLogxK

U2 - 10.1161/01.RES.0000207408.31270.db

DO - 10.1161/01.RES.0000207408.31270.db

M3 - Article

VL - 98

SP - 606

EP - 616

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 5

ER -