Folate and colorectal neoplasia: Relation between plasma and dietary markers of folate and adenoma recurrence

María Elena Martínez, Susanne M. Henning, David S Alberts

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background: The results of epidemiologic studies indicate that higher intakes or blood concentrations of folate are associated with a lower risk of colorectal neoplasia; however, only one study assessed the role of homocysteine. Objective: We assessed the relation between biochemical and dietary, markers of folate status and colorectal adenoma recurrence. Design: Analyses were conducted in 1014 men and women aged 40-80 y who had undergone removal of all colorectal polyps. Diet and supplement use were ascertained through a food-frequency questionnaire administered at study entry. Blood collected at baseline was used to measure plasma folate and homocysteine concentrations. Unconditional logistic regression was used to assess the odds of recurrence associated with the intakes of folate, methionine, and vitamins B-6 and B-12 and with plasma folate and homocysteine. Results: Relative to subjects in the highest quartile of plasma homocysteine, those in the lowest quartile had an odds ratio (OR) of adenoma recurrence of 0.69 (95% CI: 0.47, 1.02; P for trend = 0.02) after adjustment for confounding factors. Lower odds of recurrence were shown for higher plasma folate (OR: 0.66; 95% CI: 0.46, 0.97) and higher total intakes (dietary plus supplemental) of folate (OR: 0.61; 0.42, 0.89) and vitamin B-6 (OR: 0.65; 0.45, 0.94). Slightly weaker and nonsignificant associations were shown for dietary folate, methionine, and total vitamin B-12. Conclusions: A lower recurrence of colorectal adenomas was shown in subjects with higher intakes and plasma concentrations of folate. Additional markers involved in folate metabolism, including lower homocysteine and higher vitamin B-6 intake, were also associated with lower odds of recurrence.

Original languageEnglish (US)
Pages (from-to)691-697
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume79
Issue number4
StatePublished - Apr 2004

Fingerprint

adenoma
Folic Acid
folic acid
Adenoma
Recurrence
neoplasms
homocysteine
Homocysteine
Neoplasms
odds ratio
Vitamin B 6
pyridoxine
Odds Ratio
Methionine
methionine
blood
food frequency questionnaires
vitamin B12
Vitamin B 12
Polyps

Keywords

  • Colorectal adenoma
  • Folate
  • Homocysteine
  • Methionine
  • Vitamin B-12
  • Vitamin B-6

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Folate and colorectal neoplasia : Relation between plasma and dietary markers of folate and adenoma recurrence. / Martínez, María Elena; Henning, Susanne M.; Alberts, David S.

In: American Journal of Clinical Nutrition, Vol. 79, No. 4, 04.2004, p. 691-697.

Research output: Contribution to journalArticle

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abstract = "Background: The results of epidemiologic studies indicate that higher intakes or blood concentrations of folate are associated with a lower risk of colorectal neoplasia; however, only one study assessed the role of homocysteine. Objective: We assessed the relation between biochemical and dietary, markers of folate status and colorectal adenoma recurrence. Design: Analyses were conducted in 1014 men and women aged 40-80 y who had undergone removal of all colorectal polyps. Diet and supplement use were ascertained through a food-frequency questionnaire administered at study entry. Blood collected at baseline was used to measure plasma folate and homocysteine concentrations. Unconditional logistic regression was used to assess the odds of recurrence associated with the intakes of folate, methionine, and vitamins B-6 and B-12 and with plasma folate and homocysteine. Results: Relative to subjects in the highest quartile of plasma homocysteine, those in the lowest quartile had an odds ratio (OR) of adenoma recurrence of 0.69 (95{\%} CI: 0.47, 1.02; P for trend = 0.02) after adjustment for confounding factors. Lower odds of recurrence were shown for higher plasma folate (OR: 0.66; 95{\%} CI: 0.46, 0.97) and higher total intakes (dietary plus supplemental) of folate (OR: 0.61; 0.42, 0.89) and vitamin B-6 (OR: 0.65; 0.45, 0.94). Slightly weaker and nonsignificant associations were shown for dietary folate, methionine, and total vitamin B-12. Conclusions: A lower recurrence of colorectal adenomas was shown in subjects with higher intakes and plasma concentrations of folate. Additional markers involved in folate metabolism, including lower homocysteine and higher vitamin B-6 intake, were also associated with lower odds of recurrence.",
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