Folate deficiency and cervical dysplasia

C. E. Butterworth, Kenneth D Hatch, Maurizio Macaluso, Philip Cole, Howerde E. Sauberlich, Seng Jaw Soong, Matthew Borst, Vicki V. Baker

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Objective. - To test the hypothesis that nutritional deficiency affects the incidence of cervical dysplasia in young women. Design and Setting. - Case-control study. Participants were derived from community family-planning clinics and referrals to a colposcopy center. Participants. - A total of 726 subjects were screened, yielding 294 cases of dysplasia and 170 controls defined by coexistent cytologic and colposcopic evidence. Main Outcome Measures. - Planned prior to data collection. Odds ratios were computed using logistic regression models to evaluate association between cervical dysplasia and sociodemographic, sexual, and reproductive factors; smoking; oral contraceptive use; human papillomavirus (HPV) infection; and 12 nutritional indices determined by blind analysis of nonfasting blood specimens. Results. - The number of sexual partners, parity, oral contraceptive use, and HPV-16 infection were significantly associated with cervical dysplasia. Plasma nutrient levels were generally not associated with risk. However, red blood cell folate levels at or below 660 nmol/L interacted with HPV-16 infection. The adjusted odds ratio for HPV-16 was 1.1 among women with folate levels above 660 nmol/L but 5.1 (95% confidence interval, 2.3 to 11) among women with lower levels. Interactions of red blood cell folate levels with cigarette smoking and parity were also present but were not statistically significant. Conclusion. - Low red blood cell folate levels enhance the effect of other risk factors for cervical dysplasia and, in particular, that of HPV-16 infection.

Original languageEnglish (US)
Pages (from-to)528-533
Number of pages6
JournalJournal of the American Medical Association
Volume267
Issue number4
StatePublished - Jan 22 1992

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Uterine Cervical Dysplasia
Papillomavirus Infections
Human papillomavirus 16
Folic Acid
Erythrocytes
Oral Contraceptives
Parity
Logistic Models
Smoking
Odds Ratio
Colposcopy
Nutrition Assessment
Sexual Partners
Family Planning Services
Malnutrition
Case-Control Studies
Referral and Consultation
Outcome Assessment (Health Care)
Confidence Intervals
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Butterworth, C. E., Hatch, K. D., Macaluso, M., Cole, P., Sauberlich, H. E., Soong, S. J., ... Baker, V. V. (1992). Folate deficiency and cervical dysplasia. Journal of the American Medical Association, 267(4), 528-533.

Folate deficiency and cervical dysplasia. / Butterworth, C. E.; Hatch, Kenneth D; Macaluso, Maurizio; Cole, Philip; Sauberlich, Howerde E.; Soong, Seng Jaw; Borst, Matthew; Baker, Vicki V.

In: Journal of the American Medical Association, Vol. 267, No. 4, 22.01.1992, p. 528-533.

Research output: Contribution to journalArticle

Butterworth, CE, Hatch, KD, Macaluso, M, Cole, P, Sauberlich, HE, Soong, SJ, Borst, M & Baker, VV 1992, 'Folate deficiency and cervical dysplasia', Journal of the American Medical Association, vol. 267, no. 4, pp. 528-533.
Butterworth CE, Hatch KD, Macaluso M, Cole P, Sauberlich HE, Soong SJ et al. Folate deficiency and cervical dysplasia. Journal of the American Medical Association. 1992 Jan 22;267(4):528-533.
Butterworth, C. E. ; Hatch, Kenneth D ; Macaluso, Maurizio ; Cole, Philip ; Sauberlich, Howerde E. ; Soong, Seng Jaw ; Borst, Matthew ; Baker, Vicki V. / Folate deficiency and cervical dysplasia. In: Journal of the American Medical Association. 1992 ; Vol. 267, No. 4. pp. 528-533.
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