Food safety and pharmacokinetic studies which support a zero (0) meat and milk withdrawal time for use of sometribove in dairy cows.

B. G. Hammond, Robert J Collier, M. A. Miller, M. McGrath, D. L. Hartzell, C. Kotts, W. Vandaele

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Sometribove (SB) is a synthetic form of bovine somatotropin (BST) whose amino acid sequence is the same for 190 of the 191 amino acids in BST. Administration of 500 mg of SB to dairy cows every 14 d increases the efficiency of milk production. Regulatory agencies have authorized a zero (0) milk and meat withdrawal time for investigational use of SB. The scientific basis for this authorization is as follows: 1) BST and other non-primate somatotropins are not active in humans, due to differences in the amino acid sequence from human somatotropin, which limits the ability of BST to bind to receptors on human tissues. 2) SB is not orally active, as it is degraded like other proteins when eaten. Administration of 50,000 microgram/kg/d SB to rats for 90 d produced no growth response. 3) Residual levels of SB in meat/milk are very low (ppb) and comparable to endogenous BST levels. 4) Residual levels (ppb) of insulin-like growth factor I (IGF-I) in meat and milk are only marginally increased by SB treatment (somatotropin stimulates local production of IGF-I in tissues to mediate some of its biological effects. 5) IGF-I was not orally active when fed to rats at doses ranging from 200 to 2,000 microgram/kg for 14 d.

Original languageEnglish (US)
JournalAnnales de Recherches Veterinaires
Volume21 Suppl 1
StatePublished - 1990
Externally publishedYes

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Food Safety
Meat
somatotropin
pharmacokinetics
food safety
Milk
dairy cows
Pharmacokinetics
meat
milk
Insulin-Like Growth Factor I
insulin-like growth factor I
Growth Hormone
Amino Acid Sequence
amino acid sequences
Human Growth Hormone
sometribove
rats
milk production
bovine growth hormone

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Food safety and pharmacokinetic studies which support a zero (0) meat and milk withdrawal time for use of sometribove in dairy cows. / Hammond, B. G.; Collier, Robert J; Miller, M. A.; McGrath, M.; Hartzell, D. L.; Kotts, C.; Vandaele, W.

In: Annales de Recherches Veterinaires, Vol. 21 Suppl 1, 1990.

Research output: Contribution to journalArticle

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AU - Hartzell, D. L.

AU - Kotts, C.

AU - Vandaele, W.

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