Foot-shock induced stress increases β-endorphin levels in blood but not brain

Jean Rossier, Edward D. French, Catherine Rivier, Nicholas Ling, Roger Guillemin, Floyd E. Bloom

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Abstract

FOOT-SHOCK induced stress promotes a five to sixfold increase in β-endorphin plasma levels. Similar increases were also found for ACTH plasma levels. In the hypothalamus, foot-shock induced stress promotes a decrease of β-endorphin assayed by radioimmunoassays. These data suggest that physiological increases in plasma β-endorphin levels induced by stress do not result in elevated levels of brain β-endorphin.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalNature
Volume270
Issue number5638
DOIs
StatePublished - Dec 1 1977

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Rossier, J., French, E. D., Rivier, C., Ling, N., Guillemin, R., & Bloom, F. E. (1977). Foot-shock induced stress increases β-endorphin levels in blood but not brain. Nature, 270(5638), 618-620. https://doi.org/10.1038/270618a0