Foot-shock induced stress increases β-endorphin levels in blood but not brain

Jean Rossier, Edward D French, Catherine Rivier, Nicholas Ling, Roger Guillemin, Floyd E. Bloom

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

FOOT-SHOCK induced stress promotes a five to sixfold increase in β-endorphin plasma levels. Similar increases were also found for ACTH plasma levels. In the hypothalamus, foot-shock induced stress promotes a decrease of β-endorphin assayed by radioimmunoassays. These data suggest that physiological increases in plasma β-endorphin levels induced by stress do not result in elevated levels of brain β-endorphin.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalNature
Volume270
Issue number5638
DOIs
StatePublished - 1977
Externally publishedYes

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Endorphins
Foot
Shock
Brain
Adrenocorticotropic Hormone
Hypothalamus
Radioimmunoassay

ASJC Scopus subject areas

  • General

Cite this

Rossier, J., French, E. D., Rivier, C., Ling, N., Guillemin, R., & Bloom, F. E. (1977). Foot-shock induced stress increases β-endorphin levels in blood but not brain. Nature, 270(5638), 618-620. https://doi.org/10.1038/270618a0

Foot-shock induced stress increases β-endorphin levels in blood but not brain. / Rossier, Jean; French, Edward D; Rivier, Catherine; Ling, Nicholas; Guillemin, Roger; Bloom, Floyd E.

In: Nature, Vol. 270, No. 5638, 1977, p. 618-620.

Research output: Contribution to journalArticle

Rossier, J, French, ED, Rivier, C, Ling, N, Guillemin, R & Bloom, FE 1977, 'Foot-shock induced stress increases β-endorphin levels in blood but not brain', Nature, vol. 270, no. 5638, pp. 618-620. https://doi.org/10.1038/270618a0
Rossier, Jean ; French, Edward D ; Rivier, Catherine ; Ling, Nicholas ; Guillemin, Roger ; Bloom, Floyd E. / Foot-shock induced stress increases β-endorphin levels in blood but not brain. In: Nature. 1977 ; Vol. 270, No. 5638. pp. 618-620.
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