Footshock produces analgesia but no gastrointestinal motility effects in the rat

James J. Galligan, Frank Porreca, Thomas F. Burks

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Abstract

The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.

Original languageEnglish (US)
Pages (from-to)473-475
Number of pages3
JournalLife Sciences
Volume33
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Pharmacology

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