The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)