Forensic value of 14 novel STRs on the human Y chromosome

Alan J. Redd, Al B. Agellon, Veronica A. Kearney, Veronica A. Contreras, Tatiana Karafet, Hwayong Park, Peter De Knijff, John M. Butler, Michael F Hammer

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.

Original languageEnglish (US)
Pages (from-to)97-111
Number of pages15
JournalForensic Science International
Volume130
Issue number2-3
DOIs
StatePublished - Dec 4 2002

Fingerprint

Chromosomes, Human, Y
Chromosomes
Microsatellite Repeats
Cells
Cell Line
Y Chromosome
Terminology
Population
Genes
Databases

Keywords

  • DYS446
  • DYS447
  • DYS448
  • DYS449
  • DYS450
  • DYS452
  • DYS453
  • DYS454
  • DYS455
  • DYS456
  • DYS458
  • DYS459
  • DYS463
  • DYS464
  • Gene diversity
  • Humans
  • Microsatellite
  • Short-Tandem-Repeat (STR)
  • Y-chromosome
  • Y-STR

ASJC Scopus subject areas

  • Genetics
  • Analytical Chemistry
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health

Cite this

Forensic value of 14 novel STRs on the human Y chromosome. / Redd, Alan J.; Agellon, Al B.; Kearney, Veronica A.; Contreras, Veronica A.; Karafet, Tatiana; Park, Hwayong; De Knijff, Peter; Butler, John M.; Hammer, Michael F.

In: Forensic Science International, Vol. 130, No. 2-3, 04.12.2002, p. 97-111.

Research output: Contribution to journalArticle

Redd, AJ, Agellon, AB, Kearney, VA, Contreras, VA, Karafet, T, Park, H, De Knijff, P, Butler, JM & Hammer, MF 2002, 'Forensic value of 14 novel STRs on the human Y chromosome', Forensic Science International, vol. 130, no. 2-3, pp. 97-111. https://doi.org/10.1016/S0379-0738(02)00347-X
Redd, Alan J. ; Agellon, Al B. ; Kearney, Veronica A. ; Contreras, Veronica A. ; Karafet, Tatiana ; Park, Hwayong ; De Knijff, Peter ; Butler, John M. ; Hammer, Michael F. / Forensic value of 14 novel STRs on the human Y chromosome. In: Forensic Science International. 2002 ; Vol. 130, No. 2-3. pp. 97-111.
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