Abstract
We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.
Original language | English (US) |
---|---|
Pages (from-to) | 97-111 |
Number of pages | 15 |
Journal | Forensic Science International |
Volume | 130 |
Issue number | 2-3 |
DOIs | |
State | Published - Dec 4 2002 |
Fingerprint
Keywords
- DYS446
- DYS447
- DYS448
- DYS449
- DYS450
- DYS452
- DYS453
- DYS454
- DYS455
- DYS456
- DYS458
- DYS459
- DYS463
- DYS464
- Gene diversity
- Humans
- Microsatellite
- Short-Tandem-Repeat (STR)
- Y-chromosome
- Y-STR
ASJC Scopus subject areas
- Genetics
- Analytical Chemistry
- Pathology and Forensic Medicine
- Psychiatry and Mental health
Cite this
Forensic value of 14 novel STRs on the human Y chromosome. / Redd, Alan J.; Agellon, Al B.; Kearney, Veronica A.; Contreras, Veronica A.; Karafet, Tatiana; Park, Hwayong; De Knijff, Peter; Butler, John M.; Hammer, Michael F.
In: Forensic Science International, Vol. 130, No. 2-3, 04.12.2002, p. 97-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Forensic value of 14 novel STRs on the human Y chromosome
AU - Redd, Alan J.
AU - Agellon, Al B.
AU - Kearney, Veronica A.
AU - Contreras, Veronica A.
AU - Karafet, Tatiana
AU - Park, Hwayong
AU - De Knijff, Peter
AU - Butler, John M.
AU - Hammer, Michael F
PY - 2002/12/4
Y1 - 2002/12/4
N2 - We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.
AB - We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.
KW - DYS446
KW - DYS447
KW - DYS448
KW - DYS449
KW - DYS450
KW - DYS452
KW - DYS453
KW - DYS454
KW - DYS455
KW - DYS456
KW - DYS458
KW - DYS459
KW - DYS463
KW - DYS464
KW - Gene diversity
KW - Humans
KW - Microsatellite
KW - Short-Tandem-Repeat (STR)
KW - Y-chromosome
KW - Y-STR
UR - http://www.scopus.com/inward/record.url?scp=0037021620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037021620&partnerID=8YFLogxK
U2 - 10.1016/S0379-0738(02)00347-X
DO - 10.1016/S0379-0738(02)00347-X
M3 - Article
C2 - 12477629
AN - SCOPUS:0037021620
VL - 130
SP - 97
EP - 111
JO - Forensic Science International
JF - Forensic Science International
SN - 0379-0738
IS - 2-3
ER -