Forensic value of 14 novel STRs on the human Y chromosome

Alan J. Redd; Al B. Agellon; Veronica A. Kearney; Veronica A. Contreras; Tatiana Karafet; Hwayong Park; Peter De Knijff; John M. Butler; Michael F. Hammer

doi:10.1016/S0379-0738(02)00347-X

Forensic value of 14 novel STRs on the human Y chromosome

Alan J. Redd, Al B. Agellon, Veronica A. Kearney, Veronica A. Contreras, Tatiana Karafet, Hwayong Park, Peter De Knijff, John M. Butler, Michael F. Hammer

Arizona Research Labs

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.

Original language	English (US)
Pages (from-to)	97-111
Number of pages	15
Journal	Forensic Science International
Volume	130
Issue number	2-3
DOIs	https://doi.org/10.1016/S0379-0738(02)00347-X
State	Published - Dec 4 2002

Keywords

DYS446
DYS447
DYS448
DYS449
DYS450
DYS452
DYS453
DYS454
DYS455
DYS456
DYS458
DYS459
DYS463
DYS464
Gene diversity
Humans
Microsatellite
Short-Tandem-Repeat (STR)
Y-STR
Y-chromosome

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S0379-0738(02)00347-X

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Forensic value of 14 novel STRs on the human Y chromosome. / Redd, Alan J.; Agellon, Al B.; Kearney, Veronica A.; Contreras, Veronica A.; Karafet, Tatiana; Park, Hwayong; De Knijff, Peter; Butler, John M.; Hammer, Michael F.

In: Forensic Science International, Vol. 130, No. 2-3, 04.12.2002, p. 97-111.

Research output: Contribution to journal › Article › peer-review

@article{6978f3a6d4fd4539a583ce3bc412a4d7,

title = "Forensic value of 14 novel STRs on the human Y chromosome",

abstract = "We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.",

keywords = "DYS446, DYS447, DYS448, DYS449, DYS450, DYS452, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, DYS463, DYS464, Gene diversity, Humans, Microsatellite, Short-Tandem-Repeat (STR), Y-STR, Y-chromosome",

author = "Redd, {Alan J.} and Agellon, {Al B.} and Kearney, {Veronica A.} and Contreras, {Veronica A.} and Tatiana Karafet and Hwayong Park and {De Knijff}, Peter and Butler, {John M.} and Hammer, {Michael F.}",

note = "Funding Information: This research was supported by the National Institute of Justice Grant 2000-IJ-CX-K006 to MFH. Rex Riis kindly provided blood samples from the European–Americans. We thank Richard Schoske for sharing the beta-version of the Y-STR 20plex. We appreciate the duplicate Y-STR typing data in the YCC panel that were provided by Mark Jobling. Bruce Walsh computed the TMRCA estimates. We acknowledge Shari Garcia and Matthew Kaplan and for technical assistance and Jared Ragland for marker identification.",

year = "2002",

month = dec,

day = "4",

doi = "10.1016/S0379-0738(02)00347-X",

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T1 - Forensic value of 14 novel STRs on the human Y chromosome

AU - Redd, Alan J.

AU - Agellon, Al B.

AU - Kearney, Veronica A.

AU - Contreras, Veronica A.

AU - Karafet, Tatiana

AU - Park, Hwayong

AU - De Knijff, Peter

AU - Butler, John M.

AU - Hammer, Michael F.

N1 - Funding Information: This research was supported by the National Institute of Justice Grant 2000-IJ-CX-K006 to MFH. Rex Riis kindly provided blood samples from the European–Americans. We thank Richard Schoske for sharing the beta-version of the Y-STR 20plex. We appreciate the duplicate Y-STR typing data in the YCC panel that were provided by Mark Jobling. Bruce Walsh computed the TMRCA estimates. We acknowledge Shari Garcia and Matthew Kaplan and for technical assistance and Jared Ragland for marker identification.

PY - 2002/12/4

Y1 - 2002/12/4

N2 - We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.

AB - We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.

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KW - DYS447

KW - DYS448

KW - DYS449

KW - DYS450

KW - DYS452

KW - DYS453

KW - DYS454

KW - DYS455

KW - DYS456

KW - DYS458

KW - DYS459

KW - DYS463

KW - DYS464

KW - Gene diversity

KW - Humans

KW - Microsatellite

KW - Short-Tandem-Repeat (STR)

KW - Y-STR

KW - Y-chromosome

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DO - 10.1016/S0379-0738(02)00347-X

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AN - SCOPUS:0037021620

VL - 130

SP - 97

EP - 111

JO - Forensic Science International

JF - Forensic Science International

SN - 0379-0738

IS - 2-3

ER -

Forensic value of 14 novel STRs on the human Y chromosome

Abstract

Keywords

ASJC Scopus subject areas

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