Form and function of developing heart valves: Coordination by extracellular matrix and growth factor signaling

Joyce Schroeder, Leslie F. Jackson, David C. Lee, Todd D Camenisch

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

It is becoming clear that converging pathways coordinate early heart valve development and remodeling into functional valve leaflets. The integration of these pathways begins with macro and molecular interactions outside the cell in the extracellular matrix separating the myocardial and endocardial tissue components of the rudimentary heart. Such interactions regulate events at the cell surface through receptors, proteases, and other membrane molecules which in turn transduce signals into the cell. These signals trigger intracellular cascades that transduce cellular responses through both transcription factor and cofactor activation mediating gene induction or suppression. Chamber septation and valve formation occur from these coordinated molecular events within the endocardial cushions to sustain unidirectional blood flow and embryo viability. This review discusses the emerging connection between extracellular matrix and growth factor receptor signaling during endocardial cushion morphogenesis by highlighting the extracellular component, hyaluronan, and erbB receptor functions during early valve development.

Original languageEnglish (US)
Pages (from-to)392-403
Number of pages12
JournalJournal of Molecular Medicine
Volume81
Issue number7
DOIs
StatePublished - Jul 1 2003

Fingerprint

Endocardial Cushions
Heart Valves
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
CD44 Antigens
Growth Factor Receptors
Cell Surface Receptors
Morphogenesis
Cell Communication
Transcriptional Activation
Peptide Hydrolases
Transcription Factors
Embryonic Structures
Membranes

Keywords

  • Endocardial cushion morphogenesis
  • erbB
  • Extracellular matrix
  • Heart valve
  • Hyaluronan

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Form and function of developing heart valves : Coordination by extracellular matrix and growth factor signaling. / Schroeder, Joyce; Jackson, Leslie F.; Lee, David C.; Camenisch, Todd D.

In: Journal of Molecular Medicine, Vol. 81, No. 7, 01.07.2003, p. 392-403.

Research output: Contribution to journalArticle

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