Formation of microvascular networks: Role of stromal interactions directing angiogenic growth

James B. Hoying, Urs Utzinger, Jeffrey A. Weiss

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

In the adult, angiogenesis leads to an expanded microvascular network as new vessel segments are added to an existing microcirculation. Necessarily, growing neovessels must navigate through tissue stroma as they locate and grow toward other vessel elements. We have a growing body of evidence demonstrating that angiogenic neovessels reciprocally interact with the interstitial matrix of the stroma resulting in directed neovascular growth during angiogenesis. Given the compliance and the viscoelastic properties of collagen, neovessel guidance by the stroma is likely due to compressive strain transverse to the direction of primary tensile forces present during active tissue deformation. Similar stromal strains control the final network topology of the new microcirculation, including the distribution of arterioles, capillaries, and venules. In this case, stromal-derived stimuli must be present during the post-angiogenesis remodeling and maturation phases of neovascularization to have this effect. Interestingly, the preexisting organization of vessels prior to the start of angiogenesis has no lasting influence on the final, new network architecture. Combined, the evidence describes interplay between angiogenic neovessels and stroma that is important in directed neovessel growth and invasion. This dynamic is also likely a mechanism by which global tissue forces influence vascular form and function.

Original languageEnglish (US)
Pages (from-to)278-289
Number of pages12
JournalMicrocirculation
Volume21
Issue number4
DOIs
StatePublished - May 2014

Keywords

  • Angiogenesis
  • Matrix
  • Neovessel
  • Remodeling
  • Stroma

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Formation of microvascular networks: Role of stromal interactions directing angiogenic growth'. Together they form a unique fingerprint.

  • Cite this