Formation of self-assembled, air-stable lipid bilayer membranes on solid supports

Eric E. Ross, Bruce Bondurant, Tony Spratt, John C. Conboy, David F. O'Brien, S. Scott Saavedra

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

A successful strategy for the self-assembly and stabilization of a substrate-supported, phospholipid bilayer is described. The bilayer is self-organized by fusion of fluid vesicles, composed of bissorbylphosphatidylcholine, on an oxide surface. The supported bilayer is then polymerized in situ to produce a cross-linked structure that is stable to surfactant solutions, organic solvents, and to transfer across the air/water interface, yet retains the resistance to nonspecific protein adsorption characteristic of a fluid phosphatidylcholine bilayer.

Original languageEnglish (US)
Pages (from-to)2305-2307
Number of pages3
JournalLangmuir
Volume17
Issue number8
DOIs
StatePublished - Apr 17 2001

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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    Ross, E. E., Bondurant, B., Spratt, T., Conboy, J. C., O'Brien, D. F., & Saavedra, S. S. (2001). Formation of self-assembled, air-stable lipid bilayer membranes on solid supports. Langmuir, 17(8), 2305-2307. https://doi.org/10.1021/la0101752