Formation of self-assembled, air-stable lipid bilayer membranes on solid supports

Eric E. Ross, Bruce Bondurant, Tony Spratt, John C. Conboy, David F. O'Brien, Steven S Saavedra

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

A successful strategy for the self-assembly and stabilization of a substrate-supported, phospholipid bilayer is described. The bilayer is self-organized by fusion of fluid vesicles, composed of bissorbylphosphatidylcholine, on an oxide surface. The supported bilayer is then polymerized in situ to produce a cross-linked structure that is stable to surfactant solutions, organic solvents, and to transfer across the air/water interface, yet retains the resistance to nonspecific protein adsorption characteristic of a fluid phosphatidylcholine bilayer.

Original languageEnglish (US)
Pages (from-to)2305-2307
Number of pages3
JournalLangmuir
Volume17
Issue number8
DOIs
StatePublished - Apr 17 2001

Fingerprint

Lipid bilayers
Membrane Lipids
lipids
membranes
Membranes
Fluids
fluids
air
Phospholipids
Air
Phosphatidylcholines
Surface-Active Agents
Organic solvents
Self assembly
Oxides
self assembly
Surface active agents
Fusion reactions
Stabilization
stabilization

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Ross, E. E., Bondurant, B., Spratt, T., Conboy, J. C., O'Brien, D. F., & Saavedra, S. S. (2001). Formation of self-assembled, air-stable lipid bilayer membranes on solid supports. Langmuir, 17(8), 2305-2307. https://doi.org/10.1021/la0101752

Formation of self-assembled, air-stable lipid bilayer membranes on solid supports. / Ross, Eric E.; Bondurant, Bruce; Spratt, Tony; Conboy, John C.; O'Brien, David F.; Saavedra, Steven S.

In: Langmuir, Vol. 17, No. 8, 17.04.2001, p. 2305-2307.

Research output: Contribution to journalArticle

Ross, EE, Bondurant, B, Spratt, T, Conboy, JC, O'Brien, DF & Saavedra, SS 2001, 'Formation of self-assembled, air-stable lipid bilayer membranes on solid supports', Langmuir, vol. 17, no. 8, pp. 2305-2307. https://doi.org/10.1021/la0101752
Ross, Eric E. ; Bondurant, Bruce ; Spratt, Tony ; Conboy, John C. ; O'Brien, David F. ; Saavedra, Steven S. / Formation of self-assembled, air-stable lipid bilayer membranes on solid supports. In: Langmuir. 2001 ; Vol. 17, No. 8. pp. 2305-2307.
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