Fornix lesions selectively abolish place learning in the rat

John O'Keefe, Lynn Nadel, Simon Keightley, David Kill

Research output: Contribution to journalArticlepeer-review

270 Scopus citations


Rats with lesions in the fornix, a major afferent/efferent pathway of the hippocampus, failed on a water-finding task when place learning was required but succeeded in the same task when cue learning was required. These data, in conjunction with earlier physiological findings, indicate that the hippocampus functions as a cognitive mapping system.

Original languageEnglish (US)
Pages (from-to)152-166
Number of pages15
JournalExperimental Neurology
Issue number1
StatePublished - Jul 1975
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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