Four years' experience with fibrin sealant in thoracic and cardiovascular surgery

T. L. Matthew, W. D. Spotnitz, I. L. Kron, T. M. Daniel, C. G. Tribble, S. P. Nolan

Research output: Contribution to journalShort survey

7 Scopus citations


A single-donor fibrin sealant system was used in 689 thoracic and cardiovascular surgical procedures over the 4-year period between April 1, 1985, and March 31, 1989. An excellent overall success rate (646/689, 94% effective) was achieved with specific applications, including reduction of leakage of air (29/33, 88% effective), blood (595/ 634, 94% effective), and fluid (14/14, 100% effective), as well as positioning of anatomical structures such as coronary bypass grafts (8/8, 100% effective). Application methods included use of spray bottles (477/497, 96% effective), syringes (165/186, 89% effective), and a Silastic cannula through the flexible fiber-optic bronchoscope (4/6, 67% effective). The system was used in a wide variety of cardiac, pulmonary, esophageal, and vascular procedures to seal staple lines, suture lines, anastomoses, conduits, fistulas, and raw surfaces. No complications with this single-donor system secondary to blood-borne disease have been documented. Overall infection occurred at a nominal rate (16/689, 2%). Thus, fibrin sealant has been a useful tool to control the leakage of air, blood, acid fluid during a wide variety of thoracic and cardiovascular procedures and may be of benefit to other surgeons.

Original languageEnglish (US)
Pages (from-to)592-593
Number of pages2
JournalAnnals of Thoracic Surgery
Issue number2
Publication statusPublished - Jan 1 1998
Externally publishedYes


ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Matthew, T. L., Spotnitz, W. D., Kron, I. L., Daniel, T. M., Tribble, C. G., & Nolan, S. P. (1998). Four years' experience with fibrin sealant in thoracic and cardiovascular surgery. Annals of Thoracic Surgery, 65(2), 592-593.