Fragile hearts: New insights into translational control in cardiac muscle

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Current investigations focused on RNA-binding proteins in striated muscle, which provide a scenario whereby muscle function and development are governed by the interplay of post-transcriptional RNA regulation, including transcript localization, splicing, stability, and translational control. New data have recently emerged, linking the RNA-binding protein FXR1 to the translation of key cytoskeletal components such as talin and desmoplakin in heart muscle. These findings, together with a plethora of recent reports implicating RNA-binding proteins and their RNA targets in both basic aspects of muscle development and differentiation as well as heart disease and muscular dystrophies, point to a critical role of RNA-based regulatory mechanisms in muscle biology. Here we focus on FXR1, the striated muscle-specific member of the Fragile X family of RNA-binding proteins and discuss its newly reported cytoskeletal targets as well as potential implications for heart disease.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume23
Issue number8
DOIs
StatePublished - Nov 2013

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RNA-Binding Proteins
Myocardium
Striated Muscle
Muscle Development
RNA
Heart Diseases
Desmoplakins
Talin
Muscular Dystrophies
Muscles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Fragile hearts : New insights into translational control in cardiac muscle. / Zarnescu, Daniela C; Gregorio, Carol.

In: Trends in Cardiovascular Medicine, Vol. 23, No. 8, 11.2013, p. 275-281.

Research output: Contribution to journalArticle

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