Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology

Brendan Frett, Francesca Carlomagno, Maria Luisa Moccia, Annalisa Brescia, Giorgia Federico, Valentina De Falco, Brittany Admire, Zhongzhu Chen, Wenqing Qi, Massimo Santoro, Hong Yu Li

Research output: Contribution to journalArticle

4 Citations (Scopus)
Original languageEnglish (US)
JournalAngewandte Chemie - International Edition
DOIs
StateAccepted/In press - 2015

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Polypharmacology
Proto-Oncogene Proteins c-ret
Vascular Endothelial Growth Factor Receptor-2
NIH 3T3 Cells
Phosphorylation
Molecular Models
Pharmaceutical Chemistry
HEK293 Cells
Drug Design
Human Umbilical Vein Endothelial Cells
Protein Kinase Inhibitors
Tumor Cell Line
Nude Mice
Antineoplastic Agents
Protein-Tyrosine Kinases
Transfection
Tumors
Animals
Phosphotransferases
Oncogene Proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. / Frett, Brendan; Carlomagno, Francesca; Moccia, Maria Luisa; Brescia, Annalisa; Federico, Giorgia; De Falco, Valentina; Admire, Brittany; Chen, Zhongzhu; Qi, Wenqing; Santoro, Massimo; Li, Hong Yu.

In: Angewandte Chemie - International Edition, 2015.

Research output: Contribution to journalArticle

Frett, Brendan ; Carlomagno, Francesca ; Moccia, Maria Luisa ; Brescia, Annalisa ; Federico, Giorgia ; De Falco, Valentina ; Admire, Brittany ; Chen, Zhongzhu ; Qi, Wenqing ; Santoro, Massimo ; Li, Hong Yu. / Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. In: Angewandte Chemie - International Edition. 2015.
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AU - Santoro, Massimo

AU - Li, Hong Yu

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