Freeze-drying above room temperature

Marc S. Tesconi, Kiaresh Sepassi, Samuel H Yalkowsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume88
Issue number5
DOIs
StatePublished - 1999

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Chlorobutanol
Freeze Drying
Drying
Temperature
Vacuum
Organic compounds
Pharmaceutical Preparations
Eutectics
Equipment and Supplies
Water

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Freeze-drying above room temperature. / Tesconi, Marc S.; Sepassi, Kiaresh; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 88, No. 5, 1999, p. 501-506.

Research output: Contribution to journalArticle

Tesconi, Marc S. ; Sepassi, Kiaresh ; Yalkowsky, Samuel H. / Freeze-drying above room temperature. In: Journal of Pharmaceutical Sciences. 1999 ; Vol. 88, No. 5. pp. 501-506.
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