Frequency dependent 2H N.M.R. relaxation rates of small unilamellar phospholipid vesicles

Michael F. Brown, Amir Salmon, Ulf Henriksson, Olle Söderman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Deuterium (2H) N.M.R. spectroscopy has been used to investigate experimentally the molecular dynamics of phospholipid vesicles. 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) was deuterated specifically in both acyl chains, and aqueous suspensions of vesicles were studied above the main order-disorder transition temperature. 2H spin-lattice relaxation rates (R1)were measured at nine different magnetic field strengths, corresponding to Larmor frequencies (v0 = ω0/2Π) spanning 2.5 MHz to 61.4 MHz. Of three models considered, a model in which R1 ∝ω0-1/2 best described the 2H N.M.R. results, whereas fits to R1∝ ω0-1 or to a lorentzian plus a constant dispersion were less satisfactory. Thus a broad distribution of motions exists, which must be explained by any model for the N.M.R. relaxation of liquid-crystalline phospholipids.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalMolecular Physics
Volume69
Issue number2
DOIs
StatePublished - Feb 10 1990

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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