From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty: Determinants of Structural Progression and Symptoms

Frank W. Roemer, Chian K Kwoh, Tomoko Fujii, Michael J. Hannon, Robert M. Boudreau, David J. Hunter, Felix Eckstein, Markus R. John, Ali Guermazi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To assess structural progression in knees with no/mild radiographic osteoarthritis (OA) (i.e., Kellgren/Lawrence [K/L] grades 0–2) that will undergo knee replacement during a 5-year period; to assess differences in structural damage on magnetic resonance imaging (MRI) in knees with no/mild radiographic OA versus those with severe radiographic OA (i.e., K/L grades 3 and 4) at baseline; and to assess differences in pain levels between those groups. Methods: All participants who underwent knee replacement from baseline to 60 months were drawn from the Osteoarthritis Initiative. MRIs were assessed for bone marrow lesions (BMLs), Hoffa synovitis, and effusion synovitis (i.e., hyperintensity signal changes in the fat pad and abnormal amount of capsular distension due to intraarticular joint fluid and/or synovial thickening) at baseline and at the time point before knee replacement (T0). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) pain were used for pain characterization. WOMAC activities of daily living and KOOS quality of life were applied to characterize functional status of the included participants. Logistic regression was used to assess the association of no/mild radiographic OA with these MRI features and pain. Results: Based on inclusion criteria, 181 knees were selected. Participants were predominantly female (57.8%) with a mean age of 64.4 years. A total of 51 knees (28.2%) had no/mild radiographic OA at baseline. Of these, 51.0% progressed to severe radiographic OA. No/mild radiographic OA knees showed higher odds of BMLs in the patellofemoral joint at baseline (odds ratio [OR] 7.92 [95% confidence interval (95% CI) 3.45–18.16]) and T0 (OR 9.44 [95% CI 4.00–22.28]) compared to severe radiographic OA knees. In addition, no/mild radiographic OA knees were associated with change from no pain to pain from baseline to T0 (adjusted OR 5.48 [95% CI 1.25–24.00]). Conclusion: More than half of the knees with no/mild radiographic OA before knee replacement progressed to severe radiographic OA during 4 years of follow-up. BMLs in the patellofemoral joint were more often seen among knees that had no/mild radiographic OA. Worsening pain status may contribute to knee replacement in knees with no/mild radiographic OA.

Original languageEnglish (US)
Pages (from-to)1778-1786
Number of pages9
JournalArthritis Care and Research
Volume70
Issue number12
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

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Knee Osteoarthritis
Osteoarthritis
Arthroplasty
Knee
Joints
Pain
Synovitis
Patellofemoral Joint
Knee Injuries
Bone Marrow
Odds Ratio
Confidence Intervals
Magnetic Resonance Imaging
Ontario
Activities of Daily Living
Adipose Tissue
Logistic Models
Quality of Life

ASJC Scopus subject areas

  • Rheumatology

Cite this

From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty : Determinants of Structural Progression and Symptoms. / Roemer, Frank W.; Kwoh, Chian K; Fujii, Tomoko; Hannon, Michael J.; Boudreau, Robert M.; Hunter, David J.; Eckstein, Felix; John, Markus R.; Guermazi, Ali.

In: Arthritis Care and Research, Vol. 70, No. 12, 01.12.2018, p. 1778-1786.

Research output: Contribution to journalArticle

Roemer, FW, Kwoh, CK, Fujii, T, Hannon, MJ, Boudreau, RM, Hunter, DJ, Eckstein, F, John, MR & Guermazi, A 2018, 'From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty: Determinants of Structural Progression and Symptoms', Arthritis Care and Research, vol. 70, no. 12, pp. 1778-1786. https://doi.org/10.1002/acr.23545
Roemer, Frank W. ; Kwoh, Chian K ; Fujii, Tomoko ; Hannon, Michael J. ; Boudreau, Robert M. ; Hunter, David J. ; Eckstein, Felix ; John, Markus R. ; Guermazi, Ali. / From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty : Determinants of Structural Progression and Symptoms. In: Arthritis Care and Research. 2018 ; Vol. 70, No. 12. pp. 1778-1786.
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T2 - Determinants of Structural Progression and Symptoms

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AU - Kwoh, Chian K

AU - Fujii, Tomoko

AU - Hannon, Michael J.

AU - Boudreau, Robert M.

AU - Hunter, David J.

AU - Eckstein, Felix

AU - John, Markus R.

AU - Guermazi, Ali

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N2 - Objective: To assess structural progression in knees with no/mild radiographic osteoarthritis (OA) (i.e., Kellgren/Lawrence [K/L] grades 0–2) that will undergo knee replacement during a 5-year period; to assess differences in structural damage on magnetic resonance imaging (MRI) in knees with no/mild radiographic OA versus those with severe radiographic OA (i.e., K/L grades 3 and 4) at baseline; and to assess differences in pain levels between those groups. Methods: All participants who underwent knee replacement from baseline to 60 months were drawn from the Osteoarthritis Initiative. MRIs were assessed for bone marrow lesions (BMLs), Hoffa synovitis, and effusion synovitis (i.e., hyperintensity signal changes in the fat pad and abnormal amount of capsular distension due to intraarticular joint fluid and/or synovial thickening) at baseline and at the time point before knee replacement (T0). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) pain were used for pain characterization. WOMAC activities of daily living and KOOS quality of life were applied to characterize functional status of the included participants. Logistic regression was used to assess the association of no/mild radiographic OA with these MRI features and pain. Results: Based on inclusion criteria, 181 knees were selected. Participants were predominantly female (57.8%) with a mean age of 64.4 years. A total of 51 knees (28.2%) had no/mild radiographic OA at baseline. Of these, 51.0% progressed to severe radiographic OA. No/mild radiographic OA knees showed higher odds of BMLs in the patellofemoral joint at baseline (odds ratio [OR] 7.92 [95% confidence interval (95% CI) 3.45–18.16]) and T0 (OR 9.44 [95% CI 4.00–22.28]) compared to severe radiographic OA knees. In addition, no/mild radiographic OA knees were associated with change from no pain to pain from baseline to T0 (adjusted OR 5.48 [95% CI 1.25–24.00]). Conclusion: More than half of the knees with no/mild radiographic OA before knee replacement progressed to severe radiographic OA during 4 years of follow-up. BMLs in the patellofemoral joint were more often seen among knees that had no/mild radiographic OA. Worsening pain status may contribute to knee replacement in knees with no/mild radiographic OA.

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