From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases

Dirk Eick, Andrew Wedel, Hermann Heumann

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Multisubunit RNA polymerases in prokaryotes and eukaryotes share an evolutionarily conserved core. Here, we compare the processes of promoter recognition, transcription initiation and transcript elongation by human RNA polymerase II and by the RNA polymerase of the eubacterium Escherichia coli. Although these two polymerases have diverged widely in structure, important functions have been conserved, suggesting that the basic mechanisms of RNA transcription are similar in eukaryotes and prokaryotes.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalTrends in Genetics
Volume10
Issue number8
DOIs
StatePublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases'. Together they form a unique fingerprint.

  • Cite this