From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

Michael D. Delost, David Townsend Smith, Benton J. Anderson, Jon T Njardarson

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Oxygen heterocycles are the second most common type of heterocycles that appear as structural components of US Food and Drug Administration (FDA) approved pharmaceuticals. Analysis of our database of drugs approved through 2017, reveals 311 distinct pharmaceuticals containing at least one oxygen heterocycle. Most prevalent among these are pyranoses, with furanoses, macrolactones, morpholines, and dioxolanes rounding out the top five. The main body of this perspective is organized according to ring-size, commencing with three and four membered rings and ending with macrocycles, polymers, and unusual oxygen-containing heterocycles. For each section, all oxygen heterocycle containing drugs are presented along with a brief discussion about structural and drug application patterns.

Original languageEnglish (US)
JournalJournal of Medicinal Chemistry
DOIs
StateAccepted/In press - Jun 2 2018

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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