Frontiers in the measurement of cell and tissue pH

Robert J. Gillies, Ron Lynch

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Investigation into the causes and consequences of aberrant pH regulation is entirely dependent on the ability to measure this parameter with specificity and sensitivity. Since their beginnings in the 1950s, techniques for measuring cell and tissue pH have undergone a number of significant advances. Following each of these advances, new investigators have been brought into the field, and new discoveries have been made. From microelectrode and dye distribution studies, measurement of pH underwent a revolution with the advent of pH-sensitive dyes that could be loaded into the cytosol. A further significant advance came from the measurement of cell and tissue pH in whole organisms by magnetic resonance spectroscopy (MRS). Frontiers in pH measurement exist in the development of pH-sensitive proteins and pH-sensitive MR contrast agents. These are predicted to bring even more people into this fascinating field, and generate more important discoveries.

Original languageEnglish (US)
Title of host publicationNovartis Foundation Symposium
Pages7-19
Number of pages13
Volume240
StatePublished - 2001

Publication series

NameNovartis Foundation Symposium
Volume240

Fingerprint

Coloring Agents
Microelectrodes
Cytosol
Contrast Media
Magnetic Resonance Spectroscopy
Research Personnel
Sensitivity and Specificity
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gillies, R. J., & Lynch, R. (2001). Frontiers in the measurement of cell and tissue pH. In Novartis Foundation Symposium (Vol. 240, pp. 7-19). (Novartis Foundation Symposium; Vol. 240).

Frontiers in the measurement of cell and tissue pH. / Gillies, Robert J.; Lynch, Ron.

Novartis Foundation Symposium. Vol. 240 2001. p. 7-19 (Novartis Foundation Symposium; Vol. 240).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gillies, RJ & Lynch, R 2001, Frontiers in the measurement of cell and tissue pH. in Novartis Foundation Symposium. vol. 240, Novartis Foundation Symposium, vol. 240, pp. 7-19.
Gillies RJ, Lynch R. Frontiers in the measurement of cell and tissue pH. In Novartis Foundation Symposium. Vol. 240. 2001. p. 7-19. (Novartis Foundation Symposium).
Gillies, Robert J. ; Lynch, Ron. / Frontiers in the measurement of cell and tissue pH. Novartis Foundation Symposium. Vol. 240 2001. pp. 7-19 (Novartis Foundation Symposium).
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