Functional aortic stiffness: Role of CD4<sup>+</sup> T lymphocytes

Beenish A. Majeed, Lance S. Eberson, Supannikar Tawinwung, Nicolas Larmonier, Timothy W Secomb, Douglas F Larson

Research output: Contribution to journalArticle

Abstract

The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1<sup>-/-</sup> mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1<sup>-/-</sup> mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4<sup>+</sup> T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1<sup>-/-</sup> mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4<sup>+</sup> T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling.

Original languageEnglish (US)
Article number235
JournalFrontiers in Physiology
Volume6
Issue numberAug
DOIs
StatePublished - 2015

Fingerprint

Vascular Stiffness
Angiotensin II
T-Lymphocytes
Pulse Wave Analysis
Blood Vessels
Vasoconstriction
Inbred C57BL Mouse
Lymphocytes
Adoptive Transfer
Elastic Modulus
Helper-Inducer T-Lymphocytes
Vascular Smooth Muscle
Immune System
Vascular Remodeling

Keywords

  • Angiotensin II
  • Lymphocytes
  • Pulse wave velocity
  • Vascular remodeling
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Functional aortic stiffness : Role of CD4<sup>+</sup> T lymphocytes. / Majeed, Beenish A.; Eberson, Lance S.; Tawinwung, Supannikar; Larmonier, Nicolas; Secomb, Timothy W; Larson, Douglas F.

In: Frontiers in Physiology, Vol. 6, No. Aug, 235, 2015.

Research output: Contribution to journalArticle

@article{39097ede9e5649c3ab60fc7d2420122e,
title = "Functional aortic stiffness: Role of CD4+ T lymphocytes",
abstract = "The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1-/- mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1-/- mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4+ T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1-/- mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4+ T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling.",
keywords = "Angiotensin II, Lymphocytes, Pulse wave velocity, Vascular remodeling, Vasoconstriction",
author = "Majeed, {Beenish A.} and Eberson, {Lance S.} and Supannikar Tawinwung and Nicolas Larmonier and Secomb, {Timothy W} and Larson, {Douglas F}",
year = "2015",
doi = "10.3389/fphys.2015.00235",
language = "English (US)",
volume = "6",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
number = "Aug",

}

TY - JOUR

T1 - Functional aortic stiffness

T2 - Role of CD4+ T lymphocytes

AU - Majeed, Beenish A.

AU - Eberson, Lance S.

AU - Tawinwung, Supannikar

AU - Larmonier, Nicolas

AU - Secomb, Timothy W

AU - Larson, Douglas F

PY - 2015

Y1 - 2015

N2 - The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1-/- mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1-/- mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4+ T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1-/- mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4+ T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling.

AB - The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1-/- mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1-/- mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4+ T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1-/- mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4+ T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling.

KW - Angiotensin II

KW - Lymphocytes

KW - Pulse wave velocity

KW - Vascular remodeling

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=84941000484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941000484&partnerID=8YFLogxK

U2 - 10.3389/fphys.2015.00235

DO - 10.3389/fphys.2015.00235

M3 - Article

AN - SCOPUS:84941000484

VL - 6

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - Aug

M1 - 235

ER -