Functional impairment of CD4 T cells despite normalization of T cell number in HIV

Kenneth S. Knox, Richard B. Day, Lisa M. Kohli, Chadi A. Hage, Homer L. Twigg

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalCellular Immunology
Volume242
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

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Keywords

  • CD4
  • HIV
  • Lymphocyte
  • Memory
  • Mumps
  • Proliferation
  • Tetanus

ASJC Scopus subject areas

  • Immunology

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