Functional interactions between opioid mu and delta receptors in vivo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent work has shown that δ agonists, given at dose which do not produce antinociception, increase or decrease the antinociceptive potency and efficacy of some μ agonists such as morphine without altering the rate of development of tolerance. Such studies in vivo, and others in vitro, form the basis of a hypothesis of functionally complexed μ and δ receptors. Compounds with apparent selectivity for these sites are being identified.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
StatePublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Porreca, F. (1990). Functional interactions between opioid mu and delta receptors in vivo. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..