Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Lisa M. Jacola, M. B. Schapiro, V. J. Schmithorst, A. W. Byars, R. H. Strawsburg, J. P. Szaflarski, Elena M Plante, S. K. Holland

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalNeuropediatrics
Volume37
Issue number1
DOIs
StatePublished - Feb 2006

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Middle Cerebral Artery Infarction
Language
Stroke
Magnetic Resonance Imaging

Keywords

  • fMRI
  • Language
  • Plasticity
  • Reorganization
  • Stroke

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Jacola, L. M., Schapiro, M. B., Schmithorst, V. J., Byars, A. W., Strawsburg, R. H., Szaflarski, J. P., ... Holland, S. K. (2006). Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. Neuropediatrics, 37(1), 46-52. https://doi.org/10.1055/s-2006-923934

Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. / Jacola, Lisa M.; Schapiro, M. B.; Schmithorst, V. J.; Byars, A. W.; Strawsburg, R. H.; Szaflarski, J. P.; Plante, Elena M; Holland, S. K.

In: Neuropediatrics, Vol. 37, No. 1, 02.2006, p. 46-52.

Research output: Contribution to journalArticle

Jacola, LM, Schapiro, MB, Schmithorst, VJ, Byars, AW, Strawsburg, RH, Szaflarski, JP, Plante, EM & Holland, SK 2006, 'Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke', Neuropediatrics, vol. 37, no. 1, pp. 46-52. https://doi.org/10.1055/s-2006-923934
Jacola, Lisa M. ; Schapiro, M. B. ; Schmithorst, V. J. ; Byars, A. W. ; Strawsburg, R. H. ; Szaflarski, J. P. ; Plante, Elena M ; Holland, S. K. / Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. In: Neuropediatrics. 2006 ; Vol. 37, No. 1. pp. 46-52.
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