Functional neural bases of numerosity judgments in healthy adults born preterm

Caron A.C. Clark, Yating Liu, Nicolas Lee Abbot Wright, Alan D Bedrick, Jamie O Edgin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

High rates of mathematics learning disabilities among individuals born preterm (<37 weeks GA) have spurred calls for a greater understanding of the nature of these weaknesses and their neural underpinnings. Groups of healthy, high functioning young adults born preterm and full term (n = 20) completed a symbolic and non-symbolic magnitude comparison task while undergoing functional MRI scanning. Collectively, participants showed activation in superior and inferior frontal and parietal regions previously linked to numeric processing when comparing non-symbolic magnitude arrays separated by small numeric distances. Simultaneous deactivation of the default mode network also was evident during these trials. Individuals born preterm showed increased signal change relative to their full term peers in right inferior frontal and parietal regions when comparing the non-symbolic magnitude arrays. Elevated signal change during non-symbolic task blocks was associated with poorer performance on a calculation task administered outside of the scanner. These findings indicate that healthy, high-functioning adults born preterm may recruit fronto-parietal networks more extensively when processing non-symbolic magnitudes, suggesting that approximate number system training may be an inroad for early intervention to prevent mathematics difficulties in this population.

Original languageEnglish (US)
Pages (from-to)90-99
Number of pages10
JournalBrain and Cognition
Volume118
DOIs
StatePublished - Nov 1 2017

Fingerprint

Parietal Lobe
Mathematics
Learning Disorders
Young Adult
Magnetic Resonance Imaging
Population
Numerosity
Parietal

Keywords

  • Approximate number system
  • fMRI
  • Low birth weight
  • Mathematics
  • Preterm birth

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Cite this

Functional neural bases of numerosity judgments in healthy adults born preterm. / Clark, Caron A.C.; Liu, Yating; Wright, Nicolas Lee Abbot; Bedrick, Alan D; Edgin, Jamie O.

In: Brain and Cognition, Vol. 118, 01.11.2017, p. 90-99.

Research output: Contribution to journalArticle

Clark, Caron A.C. ; Liu, Yating ; Wright, Nicolas Lee Abbot ; Bedrick, Alan D ; Edgin, Jamie O. / Functional neural bases of numerosity judgments in healthy adults born preterm. In: Brain and Cognition. 2017 ; Vol. 118. pp. 90-99.
@article{dc6c6d54c4bd4e429b578f280f7f8dc9,
title = "Functional neural bases of numerosity judgments in healthy adults born preterm",
abstract = "High rates of mathematics learning disabilities among individuals born preterm (<37 weeks GA) have spurred calls for a greater understanding of the nature of these weaknesses and their neural underpinnings. Groups of healthy, high functioning young adults born preterm and full term (n = 20) completed a symbolic and non-symbolic magnitude comparison task while undergoing functional MRI scanning. Collectively, participants showed activation in superior and inferior frontal and parietal regions previously linked to numeric processing when comparing non-symbolic magnitude arrays separated by small numeric distances. Simultaneous deactivation of the default mode network also was evident during these trials. Individuals born preterm showed increased signal change relative to their full term peers in right inferior frontal and parietal regions when comparing the non-symbolic magnitude arrays. Elevated signal change during non-symbolic task blocks was associated with poorer performance on a calculation task administered outside of the scanner. These findings indicate that healthy, high-functioning adults born preterm may recruit fronto-parietal networks more extensively when processing non-symbolic magnitudes, suggesting that approximate number system training may be an inroad for early intervention to prevent mathematics difficulties in this population.",
keywords = "Approximate number system, fMRI, Low birth weight, Mathematics, Preterm birth",
author = "Clark, {Caron A.C.} and Yating Liu and Wright, {Nicolas Lee Abbot} and Bedrick, {Alan D} and Edgin, {Jamie O}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.bandc.2017.07.011",
language = "English (US)",
volume = "118",
pages = "90--99",
journal = "Brain and Cognition",
issn = "0278-2626",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Functional neural bases of numerosity judgments in healthy adults born preterm

AU - Clark, Caron A.C.

AU - Liu, Yating

AU - Wright, Nicolas Lee Abbot

AU - Bedrick, Alan D

AU - Edgin, Jamie O

PY - 2017/11/1

Y1 - 2017/11/1

N2 - High rates of mathematics learning disabilities among individuals born preterm (<37 weeks GA) have spurred calls for a greater understanding of the nature of these weaknesses and their neural underpinnings. Groups of healthy, high functioning young adults born preterm and full term (n = 20) completed a symbolic and non-symbolic magnitude comparison task while undergoing functional MRI scanning. Collectively, participants showed activation in superior and inferior frontal and parietal regions previously linked to numeric processing when comparing non-symbolic magnitude arrays separated by small numeric distances. Simultaneous deactivation of the default mode network also was evident during these trials. Individuals born preterm showed increased signal change relative to their full term peers in right inferior frontal and parietal regions when comparing the non-symbolic magnitude arrays. Elevated signal change during non-symbolic task blocks was associated with poorer performance on a calculation task administered outside of the scanner. These findings indicate that healthy, high-functioning adults born preterm may recruit fronto-parietal networks more extensively when processing non-symbolic magnitudes, suggesting that approximate number system training may be an inroad for early intervention to prevent mathematics difficulties in this population.

AB - High rates of mathematics learning disabilities among individuals born preterm (<37 weeks GA) have spurred calls for a greater understanding of the nature of these weaknesses and their neural underpinnings. Groups of healthy, high functioning young adults born preterm and full term (n = 20) completed a symbolic and non-symbolic magnitude comparison task while undergoing functional MRI scanning. Collectively, participants showed activation in superior and inferior frontal and parietal regions previously linked to numeric processing when comparing non-symbolic magnitude arrays separated by small numeric distances. Simultaneous deactivation of the default mode network also was evident during these trials. Individuals born preterm showed increased signal change relative to their full term peers in right inferior frontal and parietal regions when comparing the non-symbolic magnitude arrays. Elevated signal change during non-symbolic task blocks was associated with poorer performance on a calculation task administered outside of the scanner. These findings indicate that healthy, high-functioning adults born preterm may recruit fronto-parietal networks more extensively when processing non-symbolic magnitudes, suggesting that approximate number system training may be an inroad for early intervention to prevent mathematics difficulties in this population.

KW - Approximate number system

KW - fMRI

KW - Low birth weight

KW - Mathematics

KW - Preterm birth

UR - http://www.scopus.com/inward/record.url?scp=85026896143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026896143&partnerID=8YFLogxK

U2 - 10.1016/j.bandc.2017.07.011

DO - 10.1016/j.bandc.2017.07.011

M3 - Article

C2 - 28802184

AN - SCOPUS:85026896143

VL - 118

SP - 90

EP - 99

JO - Brain and Cognition

JF - Brain and Cognition

SN - 0278-2626

ER -