Functionalization of ceramic liposomal nanoparticles, cerasomes, with antibodies

M. T. Stamm, Z. Zha, L. Jiang, Z. Dai, Y. Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ceramic liposomal nanoparticles, cerasomes, are functionalized with antibodies on their surfaces that act as targeting ligands. This is achieved by using the siloxane network present on the cerasome surface as the foundation for chemical treatment processes previously developed for silicon surfaces. The bio-functionality and physical integrity of the cerasomes are characterized demonstrating successful immobilization of antibodies on the cerasome surface. The surface functionalization allows the cerasomes to deliver drugs to targeted cells expressing certain types of receptors with desired selectivity and specificity, which are not possible using standard liposomes.

Original languageEnglish (US)
Title of host publication2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages1614-1617
Number of pages4
DOIs
StatePublished - Sep 1 2011
Event2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
Duration: Jun 5 2011Jun 9 2011

Publication series

Name2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Other

Other2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
CountryChina
CityBeijing
Period6/5/116/9/11

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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