Fungal and parasitic infections of the eye

Stephen A Klotz, C. C. Penn, G. J. Negvesky, S. I. Butrus

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.

Original languageEnglish (US)
Pages (from-to)662-685
Number of pages24
JournalClinical Microbiology Reviews
Volume13
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Parasitic Diseases
Mycoses
Endophthalmitis
Fungi
Parasitic Eye Infections
Fungal Eye Infections
Anatomy
Infection
Chorioretinitis
Fungemia
Acanthamoeba
Keratitis
Paranasal Sinuses
Contact Lenses
Candida
Vegetables
Cornea
Cicatrix
Communicable Diseases
Parasites

ASJC Scopus subject areas

  • Microbiology

Cite this

Fungal and parasitic infections of the eye. / Klotz, Stephen A; Penn, C. C.; Negvesky, G. J.; Butrus, S. I.

In: Clinical Microbiology Reviews, Vol. 13, No. 4, 2000, p. 662-685.

Research output: Contribution to journalArticle

Klotz, Stephen A ; Penn, C. C. ; Negvesky, G. J. ; Butrus, S. I. / Fungal and parasitic infections of the eye. In: Clinical Microbiology Reviews. 2000 ; Vol. 13, No. 4. pp. 662-685.
@article{81c02f787a7f4303bfd6c1fef8169d61,
title = "Fungal and parasitic infections of the eye",
abstract = "The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.",
author = "Klotz, {Stephen A} and Penn, {C. C.} and Negvesky, {G. J.} and Butrus, {S. I.}",
year = "2000",
doi = "10.1128/CMR.13.4.662-685.2000",
language = "English (US)",
volume = "13",
pages = "662--685",
journal = "Clinical Microbiology Reviews",
issn = "0893-8512",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Fungal and parasitic infections of the eye

AU - Klotz, Stephen A

AU - Penn, C. C.

AU - Negvesky, G. J.

AU - Butrus, S. I.

PY - 2000

Y1 - 2000

N2 - The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.

AB - The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.

UR - http://www.scopus.com/inward/record.url?scp=0033787574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033787574&partnerID=8YFLogxK

U2 - 10.1128/CMR.13.4.662-685.2000

DO - 10.1128/CMR.13.4.662-685.2000

M3 - Article

C2 - 11023963

AN - SCOPUS:0033787574

VL - 13

SP - 662

EP - 685

JO - Clinical Microbiology Reviews

JF - Clinical Microbiology Reviews

SN - 0893-8512

IS - 4

ER -