Fungal endocarditis: need for guidelines in evaluating therapy. Experience with two patients previously reported

J. N. Galgiani, D. A. Stevens

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Successful treatment of fungal endocarditis is being described with increasing frequency. Two patients, previously reported as free of disease by two different groups of investigators, subsequently died with evidence of continued disease. Both patients had been receiving antifungal chemotherapy at the time their case histories were reported. The lack of clinical signs and symptoms in fungal endocarditis, the suppression of manifestations of infection by chemotherapy, and the uncertain reliability of laboratory aids led us to suggest guidelines in reporting results of therapeutic regimens. These include avoidance of terms implying cure in patients who are concurrently maintained on chemotherapy, indication of attempts to evaluate fungemia, and minimum follow up of 1 to 2 years' duration. The potential utility of serologic studies is illustrated by the course of one of these patients.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalJournal of Thoracic and Cardiovascular Surgery
Volume73
Issue number2
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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