Fusion of disubstituted benzenes

Eric Martin, Samuel H. Yalkowsky, John E. Wells

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The entropy of fusion of 84 disubstituted benzenes was essentially constant and independent of the participation of the compounds in intramolecular or intermolecular hydrogen bonding. It was also independent of the shapes, sizes, and dipole moments of the rigid molecules studied. While the entropy of fusion was independent of these parameters, the melting point and the heat of fusion showed a direct dependence on molecular properties.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalJournal of pharmaceutical sciences
Issue number5
StatePublished - May 1979
Externally publishedYes


  • Benzenes, disubstituted—entropy of fusion, melting point, heat of fusion, structure—activity relationships
  • Entropy of fusion—disubstituted benzenes, independent of hydrogen bonding, shape, size, dipole moment of rigid molecules, structure‐activity relationships
  • Melting point—analysis, disubstituted benzenes, structure‐activity relationships

ASJC Scopus subject areas

  • Pharmaceutical Science


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