Fusion of disubstituted benzenes

E. Martin, Samuel H Yalkowsky, J. E. Wells

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The entropy of fusion of 84 disubstituted benzenes was essentially constant and independent of the participation of the compounds in intramolecular or intermolecular hydrogen bonding. It was also independent of the shapes, sizes, and dipole moments of the rigid molecules studied. While the entropy of fusion was independent of these parameters, the melting point and the heat of fusion showed a direct dependence on molecular properties.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume68
Issue number5
StatePublished - 1979
Externally publishedYes

Fingerprint

Entropy
Benzene
Fusion reactions
Hydrogen Bonding
Freezing
Hot Temperature
Dipole moment
Melting point
Hydrogen bonds
Molecules

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Fusion of disubstituted benzenes. / Martin, E.; Yalkowsky, Samuel H; Wells, J. E.

In: Journal of Pharmaceutical Sciences, Vol. 68, No. 5, 1979, p. 565-568.

Research output: Contribution to journalArticle

Martin, E, Yalkowsky, SH & Wells, JE 1979, 'Fusion of disubstituted benzenes', Journal of Pharmaceutical Sciences, vol. 68, no. 5, pp. 565-568.
Martin, E. ; Yalkowsky, Samuel H ; Wells, J. E. / Fusion of disubstituted benzenes. In: Journal of Pharmaceutical Sciences. 1979 ; Vol. 68, No. 5. pp. 565-568.
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