G-quadruplex DNA: A potential target for anti-cancer drug design

Haiyong Han, Laurence H. Hurley

Research output: Contribution to journalReview article

401 Scopus citations

Abstract

In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary structures that are four-stranded; because they are made up of guanine (G) bases, such structures are called G-quadruplexes. Considerable circumstantial evidence suggests that these structures can exist in vivo in specific regions of the genome including the telomeric ends of chromosomes and oncogene regulatory regions. Recent studies have demonstrated that small molecules can facilitate the formation of, and stabilize, G-quadruplexes. The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalTrends in Pharmacological Sciences
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'G-quadruplex DNA: A potential target for anti-cancer drug design'. Together they form a unique fingerprint.

  • Cite this