G-quadruplex DNA

A potential target for anti-cancer drug design

Haiyong Han, Laurence Hurley

Research output: Contribution to journalArticle

385 Citations (Scopus)

Abstract

In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary structures that are four-stranded; because they are made up of guanine (G) bases, such structures are called G-quadruplexes. Considerable circumstantial evidence suggests that these structures can exist in vivo in specific regions of the genome including the telomeric ends of chromosomes and oncogene regulatory regions. Recent studies have demonstrated that small molecules can facilitate the formation of, and stabilize, G-quadruplexes. The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalTrends in Pharmacological Sciences
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2000

Fingerprint

G-Quadruplexes
Drug Design
Molecules
Nucleic Acid Regulatory Sequences
DNA sequences
DNA
Guanine
Chromosomes
Pharmaceutical Preparations
Neoplasms
Genes
Oncogenes
Genome

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

G-quadruplex DNA : A potential target for anti-cancer drug design. / Han, Haiyong; Hurley, Laurence.

In: Trends in Pharmacological Sciences, Vol. 21, No. 4, 01.04.2000, p. 136-142.

Research output: Contribution to journalArticle

@article{40856faa2147484c9b14afee4712cf9c,
title = "G-quadruplex DNA: A potential target for anti-cancer drug design",
abstract = "In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary structures that are four-stranded; because they are made up of guanine (G) bases, such structures are called G-quadruplexes. Considerable circumstantial evidence suggests that these structures can exist in vivo in specific regions of the genome including the telomeric ends of chromosomes and oncogene regulatory regions. Recent studies have demonstrated that small molecules can facilitate the formation of, and stabilize, G-quadruplexes. The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article. Copyright (C) 2000 Elsevier Science Ltd.",
author = "Haiyong Han and Laurence Hurley",
year = "2000",
month = "4",
day = "1",
doi = "10.1016/S0165-6147(00)01457-7",
language = "English (US)",
volume = "21",
pages = "136--142",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - G-quadruplex DNA

T2 - A potential target for anti-cancer drug design

AU - Han, Haiyong

AU - Hurley, Laurence

PY - 2000/4/1

Y1 - 2000/4/1

N2 - In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary structures that are four-stranded; because they are made up of guanine (G) bases, such structures are called G-quadruplexes. Considerable circumstantial evidence suggests that these structures can exist in vivo in specific regions of the genome including the telomeric ends of chromosomes and oncogene regulatory regions. Recent studies have demonstrated that small molecules can facilitate the formation of, and stabilize, G-quadruplexes. The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article. Copyright (C) 2000 Elsevier Science Ltd.

AB - In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary structures that are four-stranded; because they are made up of guanine (G) bases, such structures are called G-quadruplexes. Considerable circumstantial evidence suggests that these structures can exist in vivo in specific regions of the genome including the telomeric ends of chromosomes and oncogene regulatory regions. Recent studies have demonstrated that small molecules can facilitate the formation of, and stabilize, G-quadruplexes. The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article. Copyright (C) 2000 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0034176194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034176194&partnerID=8YFLogxK

U2 - 10.1016/S0165-6147(00)01457-7

DO - 10.1016/S0165-6147(00)01457-7

M3 - Article

VL - 21

SP - 136

EP - 142

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 4

ER -