G-quadruplex DNA binding by a series of carbocyanine dyes

Sean M. Kerwin, Daekyu Sun, Jonathan T. Kern, Anupama Rangan, Pei Wang Thomas

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4′-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,N'-diethylthiacarbocyanine iodide (DTC), was found to bind to G4′-DNA. DTC was also the only dye found to inhibit human telomerase at 50 μM concentration.

Original languageEnglish (US)
Pages (from-to)2411-2414
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number18
DOIs
StatePublished - Sep 17 2001
Externally publishedYes

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Carbocyanines
G-Quadruplexes
Coloring Agents
DNA
Taq Polymerase
Telomerase
Iodides
Assays

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

G-quadruplex DNA binding by a series of carbocyanine dyes. / Kerwin, Sean M.; Sun, Daekyu; Kern, Jonathan T.; Rangan, Anupama; Thomas, Pei Wang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 18, 17.09.2001, p. 2411-2414.

Research output: Contribution to journalArticle

Kerwin, Sean M. ; Sun, Daekyu ; Kern, Jonathan T. ; Rangan, Anupama ; Thomas, Pei Wang. / G-quadruplex DNA binding by a series of carbocyanine dyes. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 18. pp. 2411-2414.
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