G-quadruplex DNA binding by a series of carbocyanine dyes

Sean M. Kerwin, Daekyu Sun, Jonathan T. Kern, Anupama Rangan, Pei Wang Thomas

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4′-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,N'-diethylthiacarbocyanine iodide (DTC), was found to bind to G4′-DNA. DTC was also the only dye found to inhibit human telomerase at 50 μM concentration.

Original languageEnglish (US)
Pages (from-to)2411-2414
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number18
DOIs
StatePublished - Sep 17 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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