GABA C receptor-mediated inhibition in the retina

Peter D. Lukasiewicz, Erika D Eggers, Botir T. Sagdullaev, Maureen A. McCall

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Inhibition at bipolar cell axon terminals regulates excitatory signaling to ganglion cells and is mediated, in part, by GABA C receptors. We investigated GABA C receptor-mediated inhibition using pharmacological approaches and genetically altered mice that lack GABA C receptors. Responses to applied GABA showed distinct time courses in various bipolar cell classes, attributable to different proportions of GABA A and GABA C receptors. The elimination of GABA C receptors in GABA C null mice reduced and shortened GABA-activated currents and light-evoked inhibitory synaptic currents (L-IPSCs) in rod bipolar cells. ERG measurements and recordings from the optic nerve showed that inner retinal function was altered in GABA C null mice. These data suggest that GABA C receptors determine the time course and extent of inhibition at bipolar cell terminals that, in turn, modulates the magnitude of excitatory transmission from bipolar cells to ganglion cells.

Original languageEnglish (US)
Pages (from-to)3289-3296
Number of pages8
JournalVision Research
Volume44
Issue number28 SPEC.ISS.
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Retina
gamma-Aminobutyric Acid
Ganglia
Presynaptic Terminals
Optic Nerve
GABA-C receptor
Pharmacology
Light

Keywords

  • Bipolar cell
  • Electroretinagram
  • GABA
  • GABA receptor null mice
  • Ganglion cell
  • Mouse retina
  • Optic nerve recording
  • Whole cell patch clamp

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Lukasiewicz, P. D., Eggers, E. D., Sagdullaev, B. T., & McCall, M. A. (2004). GABA C receptor-mediated inhibition in the retina. Vision Research, 44(28 SPEC.ISS.), 3289-3296. https://doi.org/10.1016/j.visres.2004.07.023

GABA C receptor-mediated inhibition in the retina. / Lukasiewicz, Peter D.; Eggers, Erika D; Sagdullaev, Botir T.; McCall, Maureen A.

In: Vision Research, Vol. 44, No. 28 SPEC.ISS., 12.2004, p. 3289-3296.

Research output: Contribution to journalArticle

Lukasiewicz, PD, Eggers, ED, Sagdullaev, BT & McCall, MA 2004, 'GABA C receptor-mediated inhibition in the retina', Vision Research, vol. 44, no. 28 SPEC.ISS., pp. 3289-3296. https://doi.org/10.1016/j.visres.2004.07.023
Lukasiewicz PD, Eggers ED, Sagdullaev BT, McCall MA. GABA C receptor-mediated inhibition in the retina. Vision Research. 2004 Dec;44(28 SPEC.ISS.):3289-3296. https://doi.org/10.1016/j.visres.2004.07.023
Lukasiewicz, Peter D. ; Eggers, Erika D ; Sagdullaev, Botir T. ; McCall, Maureen A. / GABA C receptor-mediated inhibition in the retina. In: Vision Research. 2004 ; Vol. 44, No. 28 SPEC.ISS. pp. 3289-3296.
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