Gait changes in a line of mice artificially selected for longer limbs

Leah M. Sparrow, Emily Pellatt, Sabrina S. Yu, David A Raichlen, Herman Pontzer, Campbell Rolian

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In legged terrestrial locomotion, the duration of stance phase, i.e., when limbs are in contact with the substrate, is positively correlated with limb length, and negatively correlated with the metabolic cost of transport. These relationships are well documented at the interspecific level, across a broad range of body sizes and travel speeds. However, such relationships are harder to evaluate within species (i.e., where natural selection operates), largely for practical reasons, including low population variance in limb length, and the presence of confounding factors such as body mass, or training. Here, we compared spatiotemporal kinematics of gait in Longshanks, a long-legged mouse line created through artificial selection, and in random-bred, mass-matched Control mice raised under identical conditions. We used a gait treadmill to test the hypothesis that Longshanks have longer stance phases and stride lengths, and decreased stride frequencies in both fore- and hind limbs, compared with Controls. Our results indicate that gait differs significantly between the two groups. Specifically, and as hypothesized, stance duration and stride length are 8-10% greater in Longshanks, while stride frequency is 8% lower than in Controls. However, there was no difference in the touch-down timing and sequence of the paws between the two lines. Taken together, these data suggest that, for a given speed, Longshanks mice take significantly fewer, longer steps to cover the same distance or running time compared to Controls, with important implications for other measures of variation among individuals in whole-organism performance, such as the metabolic cost of transport.

Original languageEnglish (US)
Article numbere3008
JournalPeerJ
Volume2017
Issue number2
DOIs
StatePublished - 2017

Fingerprint

gait
limbs (animal)
Gait
Extremities
mice
Costs and Cost Analysis
Exercise equipment
artificial selection
duration
Genetic Selection
touch (sensation)
exercise equipment
Touch
Body Size
Locomotion
kinematics
Exercise Test
Biomechanical Phenomena
Running
travel

Keywords

  • Gait
  • Limb length
  • Longshanks
  • Stance
  • Stride length

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Sparrow, L. M., Pellatt, E., Yu, S. S., Raichlen, D. A., Pontzer, H., & Rolian, C. (2017). Gait changes in a line of mice artificially selected for longer limbs. PeerJ, 2017(2), [e3008]. https://doi.org/10.7717/peerj.3008

Gait changes in a line of mice artificially selected for longer limbs. / Sparrow, Leah M.; Pellatt, Emily; Yu, Sabrina S.; Raichlen, David A; Pontzer, Herman; Rolian, Campbell.

In: PeerJ, Vol. 2017, No. 2, e3008, 2017.

Research output: Contribution to journalArticle

Sparrow, LM, Pellatt, E, Yu, SS, Raichlen, DA, Pontzer, H & Rolian, C 2017, 'Gait changes in a line of mice artificially selected for longer limbs', PeerJ, vol. 2017, no. 2, e3008. https://doi.org/10.7717/peerj.3008
Sparrow, Leah M. ; Pellatt, Emily ; Yu, Sabrina S. ; Raichlen, David A ; Pontzer, Herman ; Rolian, Campbell. / Gait changes in a line of mice artificially selected for longer limbs. In: PeerJ. 2017 ; Vol. 2017, No. 2.
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