Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma.

Serrine Lau, E. F. Domino

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A highly sensitive and specific method for quantitation of ketamine and two of its metabolites found in monkey, dog and human plasma was developed using a gas chromatography selected ion monitoring assay operated in both electron impact and chemical ionization modes. This technique yields excellent precision, reproducibility and accuracy. From 1 ng to 3 microgram of ketamine or its metabolites in 1 ml of plasma can be detected. The technique of electron capture gas chromatography is compared. All three assays were found to be quite useful but the gas chromatography mass spectrometry techniques were more specific.

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalBiomedical Mass Spectrometry
Volume4
Issue number5
StatePublished - Oct 1977
Externally publishedYes

Fingerprint

Ketamine
Metabolites
Gas chromatography
Gas Chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Assays
Electrons
Plasmas
Plasma (human)
Haplorhini
Dogs
Ions
Ionization
Monitoring

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pollution

Cite this

Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma. / Lau, Serrine; Domino, E. F.

In: Biomedical Mass Spectrometry, Vol. 4, No. 5, 10.1977, p. 317-321.

Research output: Contribution to journalArticle

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