Gastric lesions in transforming growth factor β-1 heterozygous mice

Gregory P. Boivin, Julian R. Molina, Ilona Ormsby, Grant Stemmermann, Thomas C Doetschman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Transforming growth factor β-1 (TGFβ1) is known to inhibit the growth of many epithelial cell types in culture. Consequently, it is important to determine whether it has any tumor suppressor activity in vitro. Fifteen heterozygous and eight wild type TGFβ1-deficient mice were examined to determine if there was a difference in lifespan or lesion development due to the loss of one TGFβ1 allele. Mice were killed when there was evidence of neoplasia or severe illness. There was no significant difference in the lifespan of the two groups. Hyperplastic lesions in the glandular mucosa were seen in 10 TGFβ1 (+/-) mice. These lesions were localized to the lesser curvature of the stomach, extending from the limiting ridge to the pylorus. Seven of the 10 glandular hyperplastic lesions in the TGFβ1 (+/-) mice had features similar to human gastritis cystica profunda. Associated with the glandular invasion of the muscularis were a mixed inflammatory infiltration of the surrounding muscular wall and mucosa with chronic vasculitis in the tissues adjacent to these lesions. In contrast to the distinct genotypic differences in lesion incidence observed in the glandular stomach, there was no significant difference in lesion incidence in other organs. The increased incidence of the hyperplastic lesions in the TGFβ1 (+/-) mice is highly suggestive that allelic loss of TGFβ1 plays an important role in the genesis of these lesions. However, allelic loss of TGFβ1 does not cause alterations in the incidence of neoplasia.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalLaboratory Investigation
Volume74
Issue number2
StatePublished - Feb 1996
Externally publishedYes

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Transforming Growth Factors
Stomach
Loss of Heterozygosity
Incidence
Mucous Membrane
Neoplasms
Pylorus
Gastritis
Vasculitis
Cell Culture Techniques
Epithelial Cells
Alleles
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G., & Doetschman, T. C. (1996). Gastric lesions in transforming growth factor β-1 heterozygous mice. Laboratory Investigation, 74(2), 513-518.

Gastric lesions in transforming growth factor β-1 heterozygous mice. / Boivin, Gregory P.; Molina, Julian R.; Ormsby, Ilona; Stemmermann, Grant; Doetschman, Thomas C.

In: Laboratory Investigation, Vol. 74, No. 2, 02.1996, p. 513-518.

Research output: Contribution to journalArticle

Boivin, GP, Molina, JR, Ormsby, I, Stemmermann, G & Doetschman, TC 1996, 'Gastric lesions in transforming growth factor β-1 heterozygous mice', Laboratory Investigation, vol. 74, no. 2, pp. 513-518.
Boivin GP, Molina JR, Ormsby I, Stemmermann G, Doetschman TC. Gastric lesions in transforming growth factor β-1 heterozygous mice. Laboratory Investigation. 1996 Feb;74(2):513-518.
Boivin, Gregory P. ; Molina, Julian R. ; Ormsby, Ilona ; Stemmermann, Grant ; Doetschman, Thomas C. / Gastric lesions in transforming growth factor β-1 heterozygous mice. In: Laboratory Investigation. 1996 ; Vol. 74, No. 2. pp. 513-518.
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