Gastrointestinal absorption as a function of age: Xylose absorption in healthy adults

Stephen L. Johnson, Michael Mayersohn, Kenneth A. Conrad

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Xylose oral absorption was examined in 24 healthy male subjects ranging in age from 32 to 85 years. Absorption was evaluated from xylose plasma concentration-time data after administration of a 25 gm po or a 5 gm iv dose. There was no relationship between various estimates of the rate of absorption and age. The absolute oral bioavailability or the extent of xylose absorption showed no relationship to age in our population. In contrast with previous suggestions, xylose absorption does not decline with age. General statements of decreased gastrointestinal absorption efficiency as a function of age may not be correct.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume38
Issue number3
DOIs
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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