Gastrointestinal drug receptors

T. F. Burks, J. J. Galligan, Frank Porreca

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes. For example, it may now be possible to block, selectively, subtypes of muscarinic cholinergic receptors in the gastrointestinal tract with pirenzepine and other drugs that discriminate between subtypes of muscarinic cholinergic receptors. The recognition of subtypes of adrenergic receptors may allow highly selective pharmacological activation and blockage of gastrointestinal neural and smooth muscle receptors. The development of nonpeptide receptor antagonists of gastrointestinal hormones and peptide neurotransmitters also offers promise for improved therapy of digestive diseases. Tremendous progress has occurred in recent years in defining multiple types of opioid receptors that alter gastrointestinal secretory, absorptive and motility functions. These receptors are located in the mucosa, nerves and muscle of the intestine and in the brain and spinal cord.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalJournal of Clinical Gastroenterology
Volume5
Issue numberSUPPL. 1
StatePublished - 1983

Fingerprint

Gastrointestinal Hormone Receptors
Gastrointestinal Agents
Drug Receptors
Cholinergic Receptors
Muscarinic Receptors
Pirenzepine
Opioid Receptors
Transducers
Pharmaceutical Preparations
Adrenergic Receptors
Intestines
Smooth Muscle
Neurotransmitter Agents
Gastrointestinal Tract
Spinal Cord
Mucous Membrane
Pharmacology
Muscles
Brain
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Burks, T. F., Galligan, J. J., & Porreca, F. (1983). Gastrointestinal drug receptors. Journal of Clinical Gastroenterology, 5(SUPPL. 1), 29-36.

Gastrointestinal drug receptors. / Burks, T. F.; Galligan, J. J.; Porreca, Frank.

In: Journal of Clinical Gastroenterology, Vol. 5, No. SUPPL. 1, 1983, p. 29-36.

Research output: Contribution to journalArticle

Burks, TF, Galligan, JJ & Porreca, F 1983, 'Gastrointestinal drug receptors', Journal of Clinical Gastroenterology, vol. 5, no. SUPPL. 1, pp. 29-36.
Burks, T. F. ; Galligan, J. J. ; Porreca, Frank. / Gastrointestinal drug receptors. In: Journal of Clinical Gastroenterology. 1983 ; Vol. 5, No. SUPPL. 1. pp. 29-36.
@article{500689a992b943199f85d0d79c7b166b,
title = "Gastrointestinal drug receptors",
abstract = "Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes. For example, it may now be possible to block, selectively, subtypes of muscarinic cholinergic receptors in the gastrointestinal tract with pirenzepine and other drugs that discriminate between subtypes of muscarinic cholinergic receptors. The recognition of subtypes of adrenergic receptors may allow highly selective pharmacological activation and blockage of gastrointestinal neural and smooth muscle receptors. The development of nonpeptide receptor antagonists of gastrointestinal hormones and peptide neurotransmitters also offers promise for improved therapy of digestive diseases. Tremendous progress has occurred in recent years in defining multiple types of opioid receptors that alter gastrointestinal secretory, absorptive and motility functions. These receptors are located in the mucosa, nerves and muscle of the intestine and in the brain and spinal cord.",
author = "Burks, {T. F.} and Galligan, {J. J.} and Frank Porreca",
year = "1983",
language = "English (US)",
volume = "5",
pages = "29--36",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Gastrointestinal drug receptors

AU - Burks, T. F.

AU - Galligan, J. J.

AU - Porreca, Frank

PY - 1983

Y1 - 1983

N2 - Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes. For example, it may now be possible to block, selectively, subtypes of muscarinic cholinergic receptors in the gastrointestinal tract with pirenzepine and other drugs that discriminate between subtypes of muscarinic cholinergic receptors. The recognition of subtypes of adrenergic receptors may allow highly selective pharmacological activation and blockage of gastrointestinal neural and smooth muscle receptors. The development of nonpeptide receptor antagonists of gastrointestinal hormones and peptide neurotransmitters also offers promise for improved therapy of digestive diseases. Tremendous progress has occurred in recent years in defining multiple types of opioid receptors that alter gastrointestinal secretory, absorptive and motility functions. These receptors are located in the mucosa, nerves and muscle of the intestine and in the brain and spinal cord.

AB - Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes. For example, it may now be possible to block, selectively, subtypes of muscarinic cholinergic receptors in the gastrointestinal tract with pirenzepine and other drugs that discriminate between subtypes of muscarinic cholinergic receptors. The recognition of subtypes of adrenergic receptors may allow highly selective pharmacological activation and blockage of gastrointestinal neural and smooth muscle receptors. The development of nonpeptide receptor antagonists of gastrointestinal hormones and peptide neurotransmitters also offers promise for improved therapy of digestive diseases. Tremendous progress has occurred in recent years in defining multiple types of opioid receptors that alter gastrointestinal secretory, absorptive and motility functions. These receptors are located in the mucosa, nerves and muscle of the intestine and in the brain and spinal cord.

UR - http://www.scopus.com/inward/record.url?scp=0021071096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021071096&partnerID=8YFLogxK

M3 - Article

C2 - 6140283

AN - SCOPUS:0021071096

VL - 5

SP - 29

EP - 36

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - SUPPL. 1

ER -