In view of the presence of prostaglandins in milk, studies were performed to determine if matura-tional differences are present in the gastrointestinal processing of exogenous prostaglandin F2α. Suckling (10-to 14-day-old) and weanling (30-day-old) rats were gastrically fed 3H-labeled prostaglandin F2α and killed 2 h later. Characterization of radioactivity present in the stomach from animals of both age groups revealed low prostaglandin F2α metabolism. Analyses of proximal, middle, and distal intestinal segments revealed age-related differences in prostaglandin metabolism. The amount of unmetabolized PGF2α in intestinal segments of suckling rats ranged from 11.4 to 13.5%. In weanling rats, there was a tendency toward increased amounts of intact PGF2α in proximal (16.3 ± 1.6%) and middle (17.6 ± 2.2%) regions; however, 25.9 ± 1.9% of the tissue radioactivity present in the distal small intestine of weanling rats was authentic PGF2α, significantly greater than that of the distal segment of suckling rats. The intestine of weanling rats contained greater amounts of less polar metabolites. These results indicate that orogastrically fed prostaglandin can pass through the gastrointestinal tract of developing rats and be delivered to the distal intestinal mucosa intact.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of pediatric gastroenterology and nutrition|
|State||Published - Jan 1987|
- Suckling and weanling
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health