Gastrointestinal processing of gastrically administered prostaglandin F in suckling and weanling rats

Alan D. Bedrick, Otakar Koldovský

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In view of the presence of prostaglandins in milk, studies were performed to determine if matura-tional differences are present in the gastrointestinal processing of exogenous prostaglandin F. Suckling (10-to 14-day-old) and weanling (30-day-old) rats were gastrically fed 3H-labeled prostaglandin F and killed 2 h later. Characterization of radioactivity present in the stomach from animals of both age groups revealed low prostaglandin F metabolism. Analyses of proximal, middle, and distal intestinal segments revealed age-related differences in prostaglandin metabolism. The amount of unmetabolized PGF in intestinal segments of suckling rats ranged from 11.4 to 13.5%. In weanling rats, there was a tendency toward increased amounts of intact PGF in proximal (16.3 ± 1.6%) and middle (17.6 ± 2.2%) regions; however, 25.9 ± 1.9% of the tissue radioactivity present in the distal small intestine of weanling rats was authentic PGF, significantly greater than that of the distal segment of suckling rats. The intestine of weanling rats contained greater amounts of less polar metabolites. These results indicate that orogastrically fed prostaglandin can pass through the gastrointestinal tract of developing rats and be delivered to the distal intestinal mucosa intact.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJournal of pediatric gastroenterology and nutrition
Volume6
Issue number1
DOIs
StatePublished - Jan 1987

Keywords

  • Intestine
  • Prostaglandin
  • Rat
  • Stomach
  • Suckling and weanling

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Fingerprint Dive into the research topics of 'Gastrointestinal processing of gastrically administered prostaglandin F<sub>2α</sub> in suckling and weanling rats'. Together they form a unique fingerprint.

  • Cite this